Calcium-dependent physiologic and pathologic stimulus-metabolic response coupling in hepatocytes.
Calcium-dependent physiologic and pathologic stimulus-metabolic response coupling in hepatocytes.
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DOI：
10.1016/j.ceca.2012.04.009
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发表时间：
2012-07
期刊：
影响因子：
4
通讯作者：
Thomas AP
中科院分区：
文献类型：
--
作者：
Gaspers LD;Mémin E;Thomas AP
钙信号传导中的一个循环范例是钙信号的目标响应与代谢能量产生的激活的协调，以支持该响应。这发生在许多组织中，包括心肌和骨骼肌，其中收缩活动和ATP产生由钙瞬变的频率和幅度协调调节，内分泌和外分泌细胞使用钙来驱动分泌过程，以及肝细胞，其中钙的下游靶点包括分解代谢和合成代谢过程。钙增强能量产生能力的主要机制是通过钙依赖性刺激线粒体氧化代谢，通过增加NADH的产生和呼吸链通量来实现。虽然这增强了能量供应，但它也有可能由于活性氧物质（ROS）的产生增加而导致有害后果。当潜在的胞质钙信号作为短暂的钙尖峰或振荡发生时，可以改善钙依赖性线粒体活化的负面后果，其中信号强度通过尖峰频率编码（频率调制）。频率调制增加信号保真度，并减少钙的病理影响，包括过量的线粒体ROS产生和凋亡或坏死的结果。本文综述了这些问题，在生理和病理条件下获得的肝细胞的数据。
A recurrent paradigm in calcium signaling is the coordination of the target response of the calcium signal with activation of metabolic energy production to support that response. This occurs in many tissues, including cardiac and skeletal muscle where contractile activity and ATP production are coordinately regulated by the frequency and amplitude of calcium transients, endocrine and exocrine cells that use calcium to drive the secretory process, and hepatocytes where the downstream targets of calcium include both catabolic and anabolic processes. The primary mechanism by which calcium enhances the capacity for energy production is through calcium-dependent stimulation of mitochondrial oxidative metabolism, achieved by increasing NADH production and respiratory chain flux. Although this enhances energy supply, it also has the potential for deleterious consequences resulting from increased generation of reactive oxygen species (ROS). The negative consequences of calcium-dependent mitochondrial activation can be ameliorated when the underlying cytosolic calcium signals occur as brief calcium spikes or oscillations, with signal strength encoded through the spike frequency (frequency modulation). Frequency modulation increases signal fidelity, and reduces pathological effects of calcium, including excess mitochondrial ROS production and apoptotic or necrotic outcomes. The present article reviews these issues using data obtained in hepatocytes under physiologic and pathologic conditions.
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影响因子：
64.5
作者：
Cárdenas C;Miller RA;Smith I;Bui T;Molgó J;Müller M;Vais H;Cheung KH;Yang J;Parker I;Thompson CB;Birnbaum MJ;Hallows KR;Foskett JK
通讯作者：
Foskett JK
影响因子：
3.9
作者：
Gerasimenko, J;Maruyama, Y;Gerasimenko, O
通讯作者：
Gerasimenko, O
影响因子：
7.3
作者：
Dixon, CJ;Woods, NM;Green, AK
通讯作者：
Green, AK
DOI：
10.1083/jcb.201102095
发表时间：
2011-07-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Finkel T
通讯作者：
Finkel T
影响因子：
4.1
作者：
BOVERIS, A;CHANCE, B
通讯作者：
CHANCE, B