Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center study.
Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center study.
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DOI：
10.1007/s11060-012-0847-y
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发表时间：
2012-07
影响因子：
3.9
通讯作者：
Cloughesy, Timothy
中科院分区：
文献类型：
--
作者：
Pope, Whitney B.;Qiao, Xin Joe;Kim, Hyun J.;Lai, Albert;Nghiemphu, Phioanh;Xue, Xi;Ellingson, Benjamin M.;Schiff, David;Aregawi, Dawit;Cha, Soonmee;Puduvalli, Vinay K.;Wu, Jing;Yung, Wai-Kwan A.;Young, Geoffrey S.;Vredenburgh, James;Barboriak, Dan;Abrey, Lauren E.;Mikkelsen, Tom;Jain, Rajan;Paleologos, Nina A.;Lada, Patricia;Prados, Michael;Goldin, Jonathan;Wen, Patrick Y.;Cloughesy, Timothy
我们在多中心 BRAIN 研究中测试了表观扩散系数 (ADC) 直方图分析对贝伐珠单抗治疗的复发性多形性胶质母细胞瘤 (GBM) 患者的无进展生存期 (PFS) 和总生存期 (OS) 分层的预测价值。通过从拟合两条正态分布混合曲线的 T1 加权后对比图像上的增强肿瘤区域生成 ADC 直方图，对参加 BRAIN 研究的患者 (n = 97) 的可用 MRI 进行检查。使用 Cox 比例风险比和带对数秩检验的 Kaplan-Meier 方法，测试了 ADC 分类器（包括下曲线平均 ADC (ADC-L) 和平均下曲线比例 (LCP)）对 PFS 和 OS 进行分层的能力。平均 ADC-L 为 1,209 × 10−6mm2/s ± 224 (SD)，平均 LCP 为 0.71 ± 0.23 (SD)。低 ADC-L 与较差的结果相关。 ADC-L 低于平均值与高于平均值的患者的 6 个月 PFS、总体 PFS 和 OS 的风险比分别为 3.1（95% 置信区间：1.6, 6.1；P = 0.001）、2.3（95% CI：1.3、4.0；P = 0.002）和 2.4（95% CI：1.4、4.2；P = 0.002），分别。在 ADC-L<1,209 且 LCP>0.71 的患者中，与 ADC-L>1,209 且 LCP <0.71 的患者相比，中位进展时间缩短了 2.28 倍，中位 OS 降低了 1.42 倍。 ADC 直方图分析的预测价值（其中低 ADC-L 与不良预后相关）在多中心 (BRAIN) 研究的事后分析中在接受贝伐珠单抗治疗的复发性 GBM 患者中得到证实。
We have tested the predictive value of apparent diffusion coefficient (ADC) histogram analysis in stratifying progression-free survival (PFS) and overall survival (OS) in bevacizumab-treated patients with recurrent glioblastoma multiforme (GBM) from the multi-center BRAIN study. Available MRI’s from patients enrolled in the BRAIN study (n = 97) were examined by generating ADC histograms from areas of enhancing tumor on T1 weighted post-contrast images fitted to a two normal distribution mixture curve. ADC classifiers including the mean ADC from the lower curve (ADC-L) and the mean lower curve proportion (LCP) were tested for their ability to stratify PFS and OS by using Cox proportional hazard ratios and the Kaplan–Meier method with log-rank test. Mean ADC-L was 1,209 × 10−6mm2/s ± 224 (SD), and mean LCP was 0.71 ± 0.23 (SD). Low ADC-L was associated with worse outcome. The hazard ratios for 6-month PFS, overall PFS, and OS in patients with less versus greater than mean ADC-L were 3.1 (95 % confidence interval: 1.6, 6.1; P = 0.001), 2.3 (95 % CI: 1.3, 4.0; P = 0.002), and 2.4 (95 % CI: 1.4, 4.2; P = 0.002), respectively. In patients with ADC-L<1,209 and LCP>0.71 versus ADC-L>1,209 and LCP <0.71, there was a 2.28-fold reduction in the median time to progression, and a 1.42-fold decrease in the median OS. The predictive value of ADC histogram analysis, in which low ADC-L was associated with poor outcome, was confirmed in bevacizumab-treated patients with recurrent GBM in a post hoc analysis from the multi-center (BRAIN) study.
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影响因子：
5.6
作者：
Pope, Whitney B.;Young, Jonathan R.;Ellingson, Benjamin M.
通讯作者：
Ellingson, Benjamin M.
影响因子：
15.9
作者：
Lamborn, Kathleen R.;Yung, W. K. Alfred;Prados, Michael D.
通讯作者：
Prados, Michael D.
影响因子：
45.3
作者：
MACDONALD, DR;CASCINO, TL;CAIRNCROSS, JG
通讯作者：
CAIRNCROSS, JG
影响因子：
9.9
作者：
Norden, A. D.;Young, G. S.;Wen, P. Y.
通讯作者：
Wen, P. Y.
影响因子：
45.3
作者：
Friedman, Henry S.;Prados, Michael D.;Cloughesy, Timothy
通讯作者：
Cloughesy, Timothy