Air pollution and adverse cardiac remodeling: clinical effects and basic mechanisms.
Air pollution and adverse cardiac remodeling: clinical effects and basic mechanisms.
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DOI：
10.3389/fphys.2015.00162
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发表时间：
2015
影响因子：
4
通讯作者：
Chin MT
中科院分区：
文献类型：
--
作者：
Liu Y;Goodson JM;Zhang B;Chin MT
长期以来，人们一直知道暴露于空气污染会引发心血管事件，主要是通过激活影响血管系统的局部和全身炎症途径。空气污染暴露对心力衰竭和心脏重塑的有害影响也已在人群中得到描述。最近在人类受试者和动物模型中的研究提供了对在不良心脏重塑中起作用的基本生理、细胞和分子机制的见解。本文将简要概述空气污染与心血管疾病之间的关系，描述空气污染暴露对心脏重塑的临床影响，描述影响人类和动物系统重塑的基本机制，并将讨论未来的研究领域。
Exposure to air pollution has long been known to trigger cardiovascular events, primarily through activation of local and systemic inflammatory pathways that affect the vasculature. Detrimental effects of air pollution exposure on heart failure and cardiac remodeling have also been described in human populations. Recent studies in both human subjects and animal models have provided insights into the basic physiological, cellular and molecular mechanisms that play a role in adverse cardiac remodeling. This review will give a brief overview of the relationship between air pollution and cardiovascular disease, describe the clinical effects of air pollution exposure on cardiac remodeling, describe the basic mechanisms that affect remodeling as described in human and animal systems and will discuss future areas of investigation.
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影响因子：
37.8
作者：
Nemmar, A;Hoet, PHM;Hoylaerts, MF
通讯作者：
Hoylaerts, MF
DOI：
10.1136/heartjnl-2014-306379
发表时间：
2015-02
期刊：
Heart (British Cardiac Society)
影响因子：
--
作者：
Chin MT
通讯作者：
Chin MT
影响因子：
10.4
作者：
Bartell SM;Longhurst J;Tjoa T;Sioutas C;Delfino RJ
通讯作者：
Delfino RJ
DOI：
10.1164/rccm.200110-026oc
发表时间：
2002-10-01
影响因子：
24.7
作者：
Nemmar, A;Hoylaerts, MF;Nemery, B
通讯作者：
Nemery, B
影响因子：
3.8
作者：
Ghelfi, Elisa;Ramos-Rhoden, Claudia;Gonzalez-Flecha, Beatriz
通讯作者：
Gonzalez-Flecha, Beatriz