Particulate air pollution, ambulatory heart rate variability, and cardiac arrhythmia in retirement community residents with coronary artery disease.
Particulate air pollution, ambulatory heart rate variability, and cardiac arrhythmia in retirement community residents with coronary artery disease.
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DOI：
10.1289/ehp.1205914
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发表时间：
2013-10
影响因子：
10.4
通讯作者：
Delfino RJ
中科院分区：
文献类型：
--
作者：
Bartell SM;Longhurst J;Tjoa T;Sioutas C;Delfino RJ
背景：心率变异性（HRV）降低与未来的心脏发病率和死亡率相关，并且在空气颗粒物健康影响的研究中经常被用作心脏自主平衡改变的标志。很少有研究评估空气污染物与心律失常之间的关联。目的：我们研究了心律失常、HRV 和空气颗粒物暴露之间的关系。方法：我们在一项队列小组研究中，对 50 名年龄≥ 71 岁、居住在加利福尼亚州洛杉矶空气盆地四个退休社区的 50 名患有冠状动脉疾病的非吸烟者进行了长达 235 小时的动态心电图测量 HRV 和心律失常。暴露量包括每小时的室外气体、每小时的交通相关和二次有机气溶胶标记物以及每日的粒径分级颗粒质量。我们使用重复测量分析，调整体动记录仪衍生的体力活动和心率、温度、星期几、季节和社区位置。结果：室性心动过速显着增加，与交通相关颗粒物、二次有机碳和臭氧标记物的增加相关。几乎没有观察到室上性心动过速之间存在一致的关联。仅在 20 名使用 ACE（血管紧张素 I 转换酶）抑制剂的参与者中，颗粒物与动态 HRV 降低显着相关。结论：虽然这些数据支持颗粒物暴露可能增加患有冠状动脉疾病的老年人室性心动过速风险的假设，但在我们的大多数参与者中，HRV 与暴露无关。这些结果与该队列之前在全身炎症、血压和 ST 段压低方面的发现一致。引用：Bartell SM、Longhurst J、Tjoa T、Sioutas C、Delfino RJ。 2013. 患有冠状动脉疾病的退休社区居民的颗粒物空气污染、动态心率变异性和心律失常。环境健康视角 121：1135–1141； http://dx.doi.org/10.1289/ehp.1205914
Background: Decreased heart rate variability (HRV) has been associated with future cardiac morbidity and mortality and is often used as a marker of altered cardiac autonomic balance in studies of health effects of airborne particulate matter. Fewer studies have evaluated associations between air pollutants and cardiac arrhythmia. Objectives: We examined relationships between cardiac arrhythmias, HRV, and exposures to airborne particulate matter. Methods: We measured HRV and arrhythmia with ambulatory electrocardiograms in a cohort panel study for up to 235 hr per participant among 50 nonsmokers with coronary artery disease who were ≥ 71 years of age and living in four retirement communities in the Los Angeles, California, Air Basin. Exposures included hourly outdoor gases, hourly traffic-related and secondary organic aerosol markers, and daily size-fractionated particle mass. We used repeated measures analyses, adjusting for actigraph-derived physical activity and heart rate, temperature, day of week, season, and community location. Results: Ventricular tachycardia was significantly increased in association with increases in markers of traffic-related particles, secondary organic carbon, and ozone. Few consistent associations were observed for supraventricular tachycardia. Particulates were significantly associated with decreased ambulatory HRV only in the 20 participants using ACE (angiotensin I–converting enzyme) inhibitors. Conclusions: Although these data support the hypothesis that particulate exposures may increase the risk of ventricular tachycardia for elderly people with coronary artery disease, HRV was not associated with exposure in most of our participants. These results are consistent with previous findings in this cohort for systemic inflammation, blood pressure, and ST segment depression. Citation: Bartell SM, Longhurst J, Tjoa T, Sioutas C, Delfino RJ. 2013. Particulate air pollution, ambulatory heart rate variability, and cardiac arrhythmia in retirement community residents with coronary artery disease. Environ Health Perspect 121:1135–1141; http://dx.doi.org/10.1289/ehp.1205914
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影响因子：
10.4
作者：
Dockery DW;Luttmann-Gibson H;Rich DQ;Link MS;Mittleman MA;Gold DR;Koutrakis P;Schwartz JD;Verrier RL
通讯作者：
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影响因子：
10.4
作者：
Delfino RJ;Sioutas C;Malik S
通讯作者：
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影响因子：
10.4
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de Hartog, Jeroen J.;Lanki, Timo;Timonen, Kirsi L.;Hoek, Gerard;Janssen, Nicole A. H.;Ibald-Mulli, Angela;Peters, Annette;Heinrich, Joachim;Tarkiainen, Tuula H.;van Grieken, Rene;van Wijnen, Joop H.;Brunekreef, Bert;Pekkanen, Juha
通讯作者：
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影响因子：
11.4
作者：
Arhami, M;Kuhn, T;Sioutas, C
通讯作者：
Sioutas, C
DOI：
10.1152/ajpheart.00825.2003
发表时间：
2004-08-01
影响因子：
4.8
作者：
Grossman, P;Wilhelm, FH;Spoerle, M
通讯作者：
Spoerle, M