Motor primitives and synergies in the spinal cord and after injury--the current state of play.

Motor primitives and synergies in the spinal cord and after injury--the current state of play.
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DOI:
10.1111/nyas.12065
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发表时间:
2013-03
影响因子:
5.2
通讯作者:
Hart CB
Hart CB
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Giszter SF;Hart CB

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模块模式生成器元素,也被称为突发协同或电机原语,已经成为描述电机行为的一种有用和重要的方式,尽管存在争议。建议这些协同元件可能包括McCrea/Rybak两层图案发生器的图案形成层的一部分,以及在脊髓中以其他方式使用。支持模块化协同作用的数据涵盖了包括人类在内的各种物种,并包括运动模式分析和神经记录。最近,协同持续和变化后的临床创伤已提出。这些新数据强调了理解运动行为的模块化结构和潜在电路的重要性,以便最好地提供原则性治疗和理解临床报道的现象。我们讨论了关于模块化的证据和不同观点,迄今为止确定的神经基础,以及该领域未来可能存在的关键问题。
Modular pattern generator elements, also known as burst synergies or motor primitives, have become a useful and important way of describing motor behavior, albeit controversial. It is suggested that these synergy elements may comprise part of the pattern shaping layers of a McCrea/Rybak two layer pattern generator, as well as being used in other ways in spinal cord. The data supporting modular synergies ranges across species including man and encompasses motor pattern analyses and neural recordings. Recently, synergy persistence and changes following clinical trauma have been presented. These new data underscore the importance of understanding the modular structure of motor behaviors and the underlying circuitry in order to best provide principled therapies and to understand phenomena reported in the clinic. We discuss the evidence and different viewpoints on modularity, the neural underpinnings identified thus far, and possible critical issues for the future of this area.
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