Expression of GABA(B) receptors is altered in brains of subjects with autism.
Expression of GABA(B) receptors is altered in brains of subjects with autism.
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DOI：
10.1007/s12311-008-0075-3
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发表时间：
2009-03
期刊：
影响因子：
3.5
通讯作者：
Thuras, Paul D.
中科院分区：
文献类型：
--
作者：
Fatemi, S. Hossein;Folsom, Timothy D.;Reutiman, Teri J.;Thuras, Paul D.
自闭症是一种神经发育障碍，通常与癫痫发作并存。γ-氨基丁酸(GABA)是脑内主要的抑制性神经递质。GABAB受体在维持脑内兴奋性/抑制性平衡中起着重要作用，GABAB受体的改变可能导致癫痫发作。我们比较了自闭症患者和匹配对照组小脑、BA9和BA40中GABAB受体亚基GABBR1和GABBR2的水平。BA9、BA40和小脑中GABBR1的表达显著降低，而小脑中GABBR2的表达显著降低。癫痫障碍的存在对观察到的GABAB受体亚单位表达的降低没有显著影响。GABAB受体亚单位的减少可能有助于解释癫痫的存在，这种发作通常与自闭症并存，以及自闭症中普遍存在的认知障碍。
Autism is a neurodevelopmental disorder that is often comorbid with seizures. Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in brain. GABAB receptors play an important role in maintaining excitatory/inhibitory balance in brain and alterations may lead to seizures. We compared levels of GABAB receptor subunits GABBR1 and GABBR2 in cerebellum, BA9 and BA40 of subjects with autism and matched controls. Levels of GABBR1 were significantly decreased in BA9, BA40, and cerebellum, while GABBR2 was significantly reduced in the cerebellum. The presence of seizure disorder did not have a significant impact on the observed reductions in GABAB receptor subunit expression. Decreases in GABAB receptor subunits may help explain the presence of seizures that are often comorbid with autism, as well as cognitive difficulties prevalent in autism.
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