Self-reported reduced sleep quality and excessive daytime sleepiness in facioscapulohumeral muscular dystrophy.
Self-reported reduced sleep quality and excessive daytime sleepiness in facioscapulohumeral muscular dystrophy.
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DOI：
10.1002/mus.27688
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发表时间：
2022-10
期刊：
影响因子：
3.4
通讯作者：
Statland, Jeffrey M.
中科院分区：
文献类型：
--
作者：
Hoffmann, Heloise M.;Malo-Juvera, Victor;Statland, Jeffrey M.
关键词：
面肩肱型肌营养不良症 (FSHD) 会导致虚弱和继发性症状，例如呼吸系统并发症和疼痛，这可能与睡眠模式异常有关。有限的研究集中在 FSHD 的睡眠上。本研究的目的是确定一大群 FSHD 参与者自我报告的睡眠质量下降 (SQ) 和白天过度嗜睡 (DS) 的患病率和相关临床特征。我们对 FSHD 协会登记处登记的自我报告 FSHD 的个人进行了一项前瞻性调查。该调查包括人口统计和临床特征、匹兹堡睡眠质量指数 (PSQI) 和 Epworth 嗜睡量表。评估描述性统计数据，并使用单向方差分析分析临床特征与 SQ 和 DS 之间的关联。小效应大小被确定为 0.01 ≥ η2 > 0.06，中效应大小为 0.06 ≥ η2 > 0.14，大效应大小为 0.14 ≥ η2。共有 690 人参与了这项调查，男女比例平均，年龄范围从 12 岁以下到 74 岁或以上。 66% 的受访者显示 SQ 降低 (PSQI > 5)（n = 392；95% 置信区间 [CI]，62.4–70.0），15% 的受访者显示 DS 过高 (>10)（n = 89；95% CI，12.2–17.9）。 SQ 和 DS 之间存在显着相关性。夜间疼痛对降低 SQ 有显着影响（P < .001，η2 = 0.192）。年龄和性别等因素对 SQ 的影响较小。医生应将监测 FSHD 患者的睡眠质量作为常规护理的一部分，特别注意潜在的可改变因素。未来的研究应该解决睡眠中疼痛的生理影响。
Facioscapulohumeral muscular dystrophy (FSHD) causes weakness and secondary associations, such as respiratory complications and pain, that can be linked to abnormal sleep patterns. Limited studies have focused on sleep in FSHD. The purpose of this study was to identify the prevalence of, and clinical features associated with, self-reported lowered sleep quality (SQ) and excessive daytime sleepiness (DS) in a large group of participants with FSHD. We conducted a prospective survey of individuals with self-reported FSHD enrolled in the FSHD Society Registry. The survey consisted of demographic and clinical characteristics, the Pittsburgh Sleep Quality Index (PSQI), and the Epworth Sleepiness Scale. Descriptive statistics were evaluated, and associations between clinical characteristics and SQ and DS were explored using one-way analysis of variance tests. Small effect size was identified as 0.01 ≥ η2 > 0.06, medium was 0.06 ≥ η2 > 0.14, and large was 0.14 ≥ η2. Six hundred ninety individuals responded to the survey, equally distributed between men and women, and spanning the age range from under 12 to 74 years of age or older. Sixty-six percent of the respondents showed reduced SQ (PSQI > 5) (n = 392; 95% confidence interval [CI], 62.4–70.0), and 15% showed excessive DS (>10) (n = 89; 95% CI, 12.2–17.9). There was a significant association between SQ and DS. Nocturnal pain had a large significant effect on lowering SQ (P < .001, η2 = 0.192). Factors including age and gender had minor effects on SQ. Physicians should monitor sleep quality of patients with FSHD as a routine part of care, with special attention to potentially modifiable factors. Future research should address the physiological effects of pain in sleep.
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作者：
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