Palatability Can Drive Feeding Independent of AgRP Neurons.
Palatability Can Drive Feeding Independent of AgRP Neurons.
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DOI：
10.1016/j.cmet.2015.07.011
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发表时间：
2015-10-06
期刊：
影响因子：
29
通讯作者：
Luquet S
中科院分区：
文献类型：
--
作者：
Denis RG;Joly-Amado A;Webber E;Langlet F;Schaeffer M;Padilla SL;Cansell C;Dehouck B;Castel J;Delbès AS;Martinez S;Lacombe A;Rouch C;Kassis N;Fehrentz JA;Martinez J;Verdié P;Hnasko TS;Palmiter RD;Krashes MJ;Güler AD;Magnan C;Luquet S
进食行为受到稳态和享乐神经基质的精确调节，这些神经基质整合了能量需求以及食物的强化和奖励方面。由于能量密集食品的来源无处不在以及随之而来的肥胖流行，了解稳态和奖励驱动喂养的净贡献变得至关重要。下丘脑的刺豚鼠相关肽分泌神经元（AgRP 神经元）提供稳态进食的主要食欲驱动力。使用神经元抑制或消融模型，我们证明对快速生长素释放肽或血清素受体激动剂的进食反应依赖于 AgRP 神经元；然而，当提供可口的食物时，AgRP 神经元对于适当的进食反应来说是可有可无的。此外，去除 AgRP 的小鼠表现出加剧的压力诱发的厌食症和可口的食物摄入——这是舒适喂养的标志。这些结果表明，当 AgRP 神经元活性受损时，对情绪和压力敏感的神经回路会受到食物适口性和多巴胺信号传导的参与和调节。
Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical due to the ubiquitous source of energy-dense foods and the consequent obesity epidemic. Hypothalamic, agouti-related peptide-secreting neurons (AgRP neurons) provide primary orexigenic drive of homeostatic feeding. Using models of neuronal inhibition or ablation we demonstrate that the feeding response to a fast, ghrelin or serotonin receptor agonist relies on AgRP neurons; however, when palatable food is provided, AgRP neurons are dispensable for an appropriate feeding response. In addition, AgRP-ablated mice present exacerbated stress-induced anorexia and palatable food intake—a hallmark of comfort feeding. These results suggest that when AgRP neuron activity is impaired, neural circuits sensitive to emotion and stress are engaged and modulated by food palatability and dopamine signaling.
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