The combined effects of X-ray radiation and hindlimb suspension on bone loss.
The combined effects of X-ray radiation and hindlimb suspension on bone loss.
复制标题
X射线辐射和后肢悬吊对骨质流失的综合影响
DOI：
10.1093/jrr/rru014
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发表时间：
2014-07
影响因子：
2
通讯作者：
Zhou G
中科院分区：
文献类型：
--
作者：
Xu D;Zhao X;Li Y;Ji Y;Zhang J;Wang J;Xie X;Zhou G
外层空间是一个复杂的环境，存在各种对骨骼代谢产生负面影响的现象，包括微重力和高能量的电离辐射。在本研究中，我们使用了四组雄性Wistar大鼠，在4GyX射线照射后接受或不接受后肢悬吊四周的治疗，以检验后肢悬吊和X射线照射是否存在联合作用。我们测试了骨小梁参数和一些细胞因子作为骨代谢的领先指标。结果表明，后肢悬吊和X射线照射可导致大鼠骨丢失明显增加。与对照组相比，后肢悬吊组骨丢失56.6%(P=0.036)，而X射线照射组骨丢失30.7%(P=0.041)。后肢悬吊与X线联合作用对骨量影响最大，下降64.8%(P=0.003)。
Outer space is a complex environment with various phenomena that negatively affect bone metabolism, including microgravity and highly energized ionizing radiation. In the present study, we used four groups of male Wistar rats treated with or without four-week hindlimb suspension after 4 Gy of X-rays to test whether there is a combined effect for hindlimb suspension and X-ray radiation. We tested trabecular parameters and some cytokines of the bone as leading indicators of bone metabolism. The results showed that hindlimb suspension and X-ray radiation could cause a significant increase in bone loss. Hindlimb suspension caused a 56.6% bone loss (P = 0.036), while X-ray radiation caused a 30.7% (P = 0.041) bone loss when compared with the control group. The combined factors of hindlimb suspension and X-rays exerted a combined effect on bone mass, with a reduction of 64.8% (P = 0.003).
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影响因子：
4.1
作者：
Lloyd, Shane A.;Bandstra, Eric R.;Willey, Jeffrey S.;Riffle, Stephanie E.;Tirado-Lee, Leidamarie;Nelson, Gregory A.;Pecaut, Michael J.;Bateman, Ted A.
通讯作者：
Bateman, Ted A.
影响因子：
4.1
作者：
Keyak, J. H.;Koyama, A. K.;Lang, T. F.
通讯作者：
Lang, T. F.
影响因子：
3.6
作者：
Dudziak, ME;Saadeh, PB;Longaker, MT
通讯作者：
Longaker, MT
影响因子：
6.2
作者：
Smith, SM;Wastney, ME;Shackelford, LC
通讯作者：
Shackelford, LC
影响因子：
4.8
作者：
Hirotani, H;Tuohy, NA;Clipstone, NA
通讯作者：
Clipstone, NA