Serum levels of immunoglobulins G1 and G4 targeting the non‐collagenous 16A domain of BP180 reflect bullous pemphigoid activity and predict bad prognosis
Serum levels of immunoglobulins G1 and G4 targeting the non‐collagenous 16A domain of BP180 reflect bullous pemphigoid activity and predict bad prognosis
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靶向 BP180 非胶原 16A 结构域的免疫球蛋白 G1 和 G4 的血清水平反映了大疱性类天疱疮的活动并预测不良预后
DOI：
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Yue
中科院分区：
文献类型：
--
作者：
Xi;Bing Liu;Qun Xu;Yang Yang;Chun;Y. Zuo;Yue
大疱性类天疱疮(BP)是一种自身免疫性表皮下大疱性疾病，不同的免疫球蛋白(Ig)G自身抗体亚类在BP的发病机制中可能起不同的作用。本研究旨在探讨特异性免疫球蛋白亚类与血压的关系。建立了检测针对BP180非胶原性16A(NC16A)结构域的免疫球蛋白亚类的酶联免疫分析(ELISA)方法。对血压与免疫球蛋白亚类及其他因素的关系进行统计学分析。治疗前4种免疫球蛋白亚类的ELISA值与疾病严重程度评分的相关系数分别为0.586、0.441、0.594、0.345和0.448。治疗后，相关系数分别为0.376、0.522、0.314、0.582和0.503。免疫球蛋白亚类的EL ISA评分与疾病严重程度评分变化的等级相关系数分别为0.801、0.66、0.575和0.463。有粘膜受累的患者血清免疫球蛋白亚类的ELISA值明显高于无粘膜受累的患者。生存分析显示，性别、IgG1、IgG4是BP的独立预测因素。结论：BP患者血清中针对BP180NC16A的IgG1和IgG4水平与疾病严重程度呈正相关。IgG1、IgG4和性别是影响BP早期预后的独立预后因素。
Bullous pemphigoid (BP) is an autoimmune subepidermal bullous disease, and different immunoglobulin (Ig)G autoantibody subclasses may play different roles in the pathogenesis of BP. This study aims to evaluate the relationship between specific IgG subclasses and BP. Enzyme‐linked immunoassays (ELISA) were developed to test the IgG subclasses targeting the non‐collagenous 16A (NC16A) domain of BP180. A statistical analysis was carried out to assess the relationship of BP and IgG subclasses as well as other factors. The correlation coefficients between the ELISA scores for four IgG subclasses and disease severity scores were 0.586 for IgG, 0.441 for IgG1, 0.594 for IgG2, 0.345 for IgG3, and 0.448 for IgG4 before treatment. After treatment, the correlation coefficient was 0.376 for IgG, 0.522 for IgG1, 0.314 for IgG2, 0.582 for IgG3 and 0.503 for IgG4. Spearman's rank correlation coefficient was 0.801 for IgG1, 0.66 for IgG2, 0.575 for IgG3 and 0.463 for IgG4 between the ELISA scores of IgG subclasses and the disease severity score variation. The ELISA scores of IgG subclasses in patients with mucosal involvement were higher than those without. Survival analysis showed that sex, IgG1 and IgG4 were the independent predictors for BP. In conclusion, the serum levels of IgG1 and IgG4 targeting BP180NC16A were paralleled with disease severity in BP patients. IgG1 and IgG4 and sex were the independent prognostic factors for an early prognosis of BP.
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影响因子：
15.9
作者：
Nelson, Kelly C.;Zhao, Minglang;Liu, Zhi
通讯作者：
Liu, Zhi
影响因子：
13.8
作者：
Murrell, Dedee F.;Daniel, Benjamin S.;Joly, Pascal;Borradori, Luca;Amagai, Masayuki;Hashimoto, Takashi;Caux, Frederic;Marinovic, Branka;Sinha, Animesh A.;Hertl, Michael;Bernard, Philippe;Sirois, David;Cianchini, Giuseppe;Fairley, Janet A.;Jonkman, Marcel F.;Pandya, Amit G.;Rubenstein, David;Zillikens, Detlef;Payne, Aimee S.;Woodley, David;Zambruno, Giovanna;Aoki, Valeria;Pincelli, Carlo;Diaz, Luis;Hall, Russell P.;Meurer, Michael;Mascaro, Jose M., Jr.;Schmidt, Enno;Shimizu, Hiroshi;Zone, John;Swerlick, Robert;Mimouni, Daniel;Culton, Donna;Lipozencic, Jasna;Bince, Benjamin;Grando, Sergei A.;Bystryn, Jean-Claude;Werth, Victoria P.
通讯作者：
Werth, Victoria P.
DOI：
10.1111/1523-1747.ep12337492
发表时间：
1997-10
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
D. Zillikens;Pamela A. Rose;S. D. Balding;Zhi Liu;M. Olague-Marchan;L. Diaz;G. Giudice
通讯作者：
D. Zillikens;Pamela A. Rose;S. D. Balding;Zhi Liu;M. Olague-Marchan;L. Diaz;G. Giudice
DOI：
10.1016/s0190-9622(00)90213-5
发表时间：
2000-03-01
影响因子：
13.8
作者：
Herbst, A;Bystryn, JC
通讯作者：
Bystryn, JC