Immunotherapeutic Potential of T Memory Stem Cells.
Immunotherapeutic Potential of T Memory Stem Cells.
复制标题
T 记忆干细胞的免疫治疗潜力。
DOI：
10.3389/fonc.2021.723888
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
Zhou S
中科院分区：
文献类型：
--
作者：
Li Y;Wu D;Yang X;Zhou S
记忆T细胞包括T记忆干细胞（TSCM）和中央记忆T细胞（TCM）。与效应记忆T细胞（TEM）和效应T细胞（TEFF）相比，它们具有更好的耐久性和抗肿瘤免疫性。最近的研究表明，尽管TSCM具有优异的自我更新能力和多功能性，但如果经常暴露于抗原和炎症信号，TSCM会表现为多种抑制性受体如PD-1、TIM-3和LAG-3的表达，以及从氧化磷酸化到糖酵解的代谢变化。这些变化会导致T细胞的耗竭。动物实验中的累积证据表明，它是记忆T淋巴细胞系统中分化程度最低的细胞，是人类许多生理和病理过程的核心参与者。具有良好的临床应用前景，因此研究影响TSCM形成的因素越来越重要。本文就TSCM的表型和功能特点、形成的调控机制及其在临床疾病治疗中的应用进行综述和展望。
Memory T cells include T memory stem cells (TSCM) and central memory T cells (TCM). Compared with effector memory T cells (TEM) and effector T cells (TEFF), they have better durability and anti-tumor immunity. Recent studies have shown that although TSCM has excellent self-renewal ability and versatility, if it is often exposed to antigens and inflammatory signals, TSCM will behave as a variety of inhibitory receptors such as PD-1, TIM-3 and LAG-3 expression, and metabolic changes from oxidative phosphorylation to glycolysis. These changes can lead to the exhaustion of T cells. Cumulative evidence in animal experiments shows that it is the least differentiated cell in the memory T lymphocyte system and is a central participant in many physiological and pathological processes in humans. It has a good clinical application prospect, so it is more and more important to study the factors affecting the formation of TSCM. This article summarizes and prospects the phenotypic and functional characteristics of TSCM, the regulation mechanism of formation, and its application in treatment of clinical diseases.
登录
查看更多内容
影响因子：
30.5
作者：
Chang CH;Pearce EL
通讯作者：
Pearce EL
影响因子：
22.7
作者：
Biasco L;Izotova N;Rivat C;Ghorashian S;Richardson R;Guvenel A;Hough R;Wynn R;Popova B;Lopes A;Pule M;Thrasher AJ;Amrolia PJ
通讯作者：
Amrolia PJ
影响因子：
20.3
作者：
Bride, Karen L.;Vincent, Tiffaney;Teachey, David T.
通讯作者：
Teachey, David T.
影响因子：
50.3
作者：
Anderson KG;Stromnes IM;Greenberg PD
通讯作者：
Greenberg PD
影响因子：
7.3
作者：
Castella, Maria;Caballero-Banos, Miguel;Juan, Manel
通讯作者：
Juan, Manel