Etiologies of Childhood Hearing Impairment in Schools for the Deaf in Mali.
Etiologies of Childhood Hearing Impairment in Schools for the Deaf in Mali.
复制标题
DOI：
10.3389/fped.2021.726776
复制
发表时间：
2021
影响因子：
2.6
通讯作者：
Wonkam A
中科院分区：
文献类型：
--
作者：
Yalcouyé A;Traoré O;Taméga A;Maïga AB;Kané F;Oluwole OG;Guinto CO;Kéita M;Timbo SK;DeKock C;Landouré G;Wonkam A
目的：确定耳聋学生学校中听力障碍（HI）的病因，并使用系统回顾总结马里HI的病因、临床和遗传特征的报告。方法：我们纳入了15岁之前开始的HI患者。根据标准实践仔细评估患者，并在可能的情况下进行纯音测听。然后，我们检索了从数据库成立到2020年3月30日在马里人群中发表的关于HI的文章。结果：共有117人从两所学校的聋人，并注意到男性占主导地位（性别比1.3; 65/52）。82.2%（n = 117）的HI发生在舌前，诊断时的中位年龄为12岁。59.4%（70/117）的病因是环境因素，脑膜炎是主要病因（40%，20/70），其次是遗传可疑病例（29.3%，21/117）。在11.3%（8/117）的患者中，未确定病因。在遗传怀疑的病例中，有3例是综合征，包括2例Waardenburg综合征，而15例患者患有非综合征性HI。83.3%（15/18）的家系为常染色体隐性遗传，55.5%（10/18）的家系为近亲遗传。结论：本研究得出结论，环境因素是马里HI的主要原因。然而，应调查遗传原因，特别是在近亲比例高的人口中。
Objectives: To identify the etiologies of hearing impairment (HI) in schools for students who are deaf and to use a systematic review to summarize reports on the etiologies and clinical and genetic features of HI in Mali. Methods: We included individuals with HI that started before the age of 15 years old. Patients were carefully evaluated under standard practices, and pure-tone audiometry was performed where possible. We then searched for articles published on HI in the Malian population from the databases' inception to March 30, 2020. Results: A total of 117 individuals from two schools for the deaf were included, and a male predominance (sex ratio 1.3; 65/52) was noted. HI was pre-lingual in 82.2% (n = 117), and the median age at diagnosis was 12 years old. The etiologies were environmental in 59.4% (70/117), with meningitis being the leading cause (40%, 20/70), followed by cases with genetic suspicion (29.3%, 21/117). In 11.3% (8/117) of patients, no etiology was identified. Among cases with genetic suspicion, three were syndromic, including two cases of Waardenburg syndrome, while 15 individuals had non-syndromic HI. An autosomal recessive inheritance pattern was observed in 83.3% of families (15/18), and consanguinity was reported in 55.5% (10/18) of putative genetic cases. Conclusion: This study concludes that environmental factors are the leading causes of HI in Mali. However, genetic causes should be investigated, particularly in the context of a population with a high consanguinity rate.
登录
查看更多内容
影响因子：
1.9
作者：
Meilleur, Katherine Gloria;Coulibaly, Souleymane;Han, Hae-Ra
通讯作者：
Han, Hae-Ra
影响因子：
2.2
作者：
Traore, M.;Landoure, G.;Fischbeck, K. H.
通讯作者：
Fischbeck, K. H.
影响因子：
2
作者：
Landouré G;Samassékou O;Traoré M;Meilleur KG;Guinto CO;Burnett BG;Sumner CJ;Fischbeck KH
通讯作者：
Fischbeck KH
影响因子：
1.3
作者：
Grindle, Christopher R.
通讯作者：
Grindle, Christopher R.
影响因子：
5.7
作者：
Moussa, Traore;Abdoulaye, Diallo;Traore, Thomas Jeannette
通讯作者：
Traore, Thomas Jeannette