Complete genome sequence of transmissible gastroenteritis coronavirus PUR46-MAD clone and evolution of the purdue virus cluster.
Complete genome sequence of transmissible gastroenteritis coronavirus PUR46-MAD clone and evolution of the purdue virus cluster.
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DOI:
10.1023/a:1011147832586
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发表时间:
2001
期刊:
影响因子:
1.6
通讯作者:
Enjuanes L
中科院分区:
文献类型:
--
作者:
Penzes Z;Gonzalez JM;Calvo E;Izeta A;Smerdou C;Méndez A;Sanchez CM;Sola I;Almazan F;Enjuanes L
The complete sequence (28580 nt) of the PUR46-MAD clone of the Purdue cluster of transmissible gastroenteritis coronavirus (TGEV) has been determined and compared with members of this cluster and other coronaviruses. The computing distances among their S gene sequences resulted in the grouping of these coronaviruses into four clusters, one of them exclusively formed by the Purdue viruses. Three new potential sequence motifs with homology to the α-subunit of the polymerase-associated nucleocapsid phosphoprotein of rinderpest virus, the Bowman–Birk type of proteinase inhibitors, and the metallothionein superfamily of cysteine rich chelating proteins have been identified. Comparison of the TGEV polymerase sequence with that of other RNA viruses revealed high sequence homology with the A–E domains of the palm subdomain of nucleic acid polymerases.
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通讯作者:
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Izeta, A;Smerdou, C;Enjuanes, L
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Enjuanes, L
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