Molecular Mechanisms Underlying Cardiac Adaptation to Exercise.
Molecular Mechanisms Underlying Cardiac Adaptation to Exercise.
复制标题
DOI：
10.1016/j.cmet.2017.04.025
复制
发表时间：
2017-05-02
期刊：
影响因子：
29
通讯作者：
Leinwand LA
中科院分区：
文献类型：
--
作者：
Vega RB;Konhilas JP;Kelly DP;Leinwand LA
运动增强了包括骨骼肌、血管、心脏和肺在内的多器官协调反应。在短期内，心脏的输出量增加，以满足剧烈运动的需求。长期运动会促使心脏重塑，包括生长和适应性分子和细胞重新编程。信号通路如胰岛素样生长因子1/PI 3 K/Akt通路介导许多这些反应。心脏收缩引起的或生理性的心脏生长与病理性刺激如高血压引起的生长形成对比。比较生理性和病理性心脏生长的分子和细胞基础，揭示了表型特异性信号通路和转录调控程序。研究表明，运动途径可能拮抗病理途径，运动训练通常推荐用于慢性稳定性心力衰竭或心肌梗死患者。在此，我们总结了目前的理解的结构和功能的心脏运动的反应，以及信号通路和下游效应分子负责这些适应。
Exercise elicits coordinated multi-organ responses including skeletal muscle, vasculature, heart and lung. In the short term, the output of the heart increases to meet the demand of strenuous exercise. Long term exercise instigates remodeling of the heart including growth and adaptive molecular and cellular re-programming. Signaling pathways such as the insulin-like growth factor 1/PI3K/Akt pathway mediate many of these responses. Exercise-induced, or physiologic, cardiac growth contrasts with growth elicited by pathological stimuli such as hypertension. Comparing the molecular and cellular underpinnings of physiologic and pathologic cardiac growth has unveiled phenotype-specific signaling pathways and transcriptional regulatory programs. Studies suggest that exercise pathways likely antagonize pathological pathways, and exercise training is often recommended for patients with chronic stable heart failure or following myocardial infarction. Herein, we summarize the current understanding of the structural and functional cardiac responses to exercise as well as signaling pathways and downstream effector molecules responsible for these adaptations.
登录
查看更多内容
影响因子：
20.1
作者：
Calvert JW;Condit ME;Aragón JP;Nicholson CK;Moody BF;Hood RL;Sindler AL;Gundewar S;Seals DR;Barouch LA;Lefer DJ
通讯作者：
Lefer DJ
影响因子：
64.5
作者：
Bersell, Kevin;Arab, Shima;Kuehn, Bernhard
通讯作者：
Kuehn, Bernhard
影响因子：
21.3
作者：
D'Uva, Gabriele;Aharonov, Alla;Tzahor, Eldad
通讯作者：
Tzahor, Eldad
DOI：
10.1097/hjr.0b013e32833158a2
发表时间：
2009-12-01
影响因子：
--
作者：
Beisvag, Vidar;Kemi, Ole Johan;Ellingsen, Oyvind
通讯作者：
Ellingsen, Oyvind
影响因子：
8
作者：
Bezzerides, Vassilios J.;Platt, Colin;Rosenzweig, Anthony
通讯作者：
Rosenzweig, Anthony