Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer.
Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer.
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作者：
长链非编码RNA（lncRNA）的异常表达与患者的预后密切相关。这一发现可能为恶性肿瘤的治疗提供新的靶点。非肌层浸润性膀胱癌（NMIBC）是膀胱癌中最常见的亚型，BCG膀胱灌注治疗是NMIBC的一线治疗方法，但约一半的NMIBC患者在BCG治疗后两年内复发。因此，筛选出与BGC耐药患者预后和治疗相关的lncRNA是必要的。在这里，我们在癌症基因组图谱（TCGA）和基因表达综合数据集（GEO）中进行了lncRNA的差异表达分析，并筛选MIR 4435 - 2 HG作为唯一的BCG反应相关lncRNA。然后，MIR 4435 - 2 HG的预后价值在几个公开可用的队列中得到验证，并证实其在不同阶段的膀胱癌中的预后价值。此外，我们还分析了其遗传改变、临床相关性、功能富集以及与其他生物标志物的关联。进一步验证MIR 4435 - 2 HG的表达可能有助于指导NMIBC的预后和治疗。
The abnormal expression of long non-coding RNAs(lncRNAs) is closely related to the prognosis of patients. This finding may indicate a new target for the treatment of malignant tumors. Non-muscle invasive bladder cancer (NMIBC) is the most common subtype of bladder cancer, and BCG intravesical therapy is the first-line treatment for NMIBC, but about half of NMIBC patients relapse within two years after BCG treatment. Therefore, it is necessary to screen out lncRNAs related to the prognosis and treatment of BGC-resistant patients. Here, we performed differential expression analysis of lncRNAs in the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets, and screened MIR4435-2HG as the only BCG-response-related lncRNA. Then, the prognosis value of MIR4435-2HG was validated in several publicly available cohorts, and confirmed its prognostic value in bladder cancer of different stages. In addition, we also analyzed its genetic alterations, clinical relevance, function enrichment, and association with other biomarkers. Further validation of the expression of MIR4435-2HG might be helpful to instruct NMIBC prognosis and treatment.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Anastasiadou E;Jacob LS;Slack FJ
通讯作者：
Slack FJ
影响因子：
7.3
作者：
Acevedo OA;Berrios RV;Rodríguez-Guilarte L;Lillo-Dapremont B;Kalergis AM
通讯作者：
Kalergis AM
影响因子：
4.6
作者：
Bonneville R;Krook MA;Kautto EA;Miya J;Wing MR;Chen HZ;Reeser JW;Yu L;Roychowdhury S
通讯作者：
Roychowdhury S
影响因子：
158.5
作者：
Grossman, HB;Natale, RB;Crawford, ED
通讯作者：
Crawford, ED