Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal.
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal.
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DOI:
10.1126/scisignal.2004088
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发表时间:
2013-04-02
影响因子:
7.3
通讯作者:
Schultz N
中科院分区:
文献类型:
--
作者:
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. The query interface combined with customized data storage enables researchers to interactively explore genetic alterations across samples, genes, and pathways and, when available in the underlying data, to link these to clinical outcomes. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, patient-centric queries, and software programmatic access. The intuitive Web interface of the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries. Here, we provide a practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics.
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影响因子:
64.8
作者:
通讯作者:
--
影响因子:
8.8
作者:
Bamford, S;Dawson, E;Forbes, S;Clements, J;Pettett, R;Dogan, A;Flanagan, A;Teague, J;Futreal, PA;Stratton, MR;Wooster, R
通讯作者:
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影响因子:
14.9
作者:
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通讯作者:
Pandey A
DOI:
10.1038/nrc1299
发表时间:
2004-03
期刊:
Nature reviews. Cancer
影响因子:
--
作者:
通讯作者:
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影响因子:
14.9
作者:
Schaefer, Carl F.;Anthony, Kira;Buetow, Kenneth H.
通讯作者:
Buetow, Kenneth H.