TTLL11 gene is associated with sustained attention performance and brain networks: A genome-wide association study of a healthy Chinese sample.
TTLL11 gene is associated with sustained attention performance and brain networks: A genome-wide association study of a healthy Chinese sample.
复制标题
TTTL11 基因与持续注意力表现和大脑网络相关：针对健康中国样本的全基因组关联研究
DOI：
10.1111/gbb.12835
复制
发表时间：
2023-02
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
对注意力的遗传研究主要集中在患有注意力缺陷/多动症（ADHD）的儿童上，因此对注意力表现的遗传相关性及其潜在的大脑机制进行的系统研究很少，当前研究中的研究包括一项基因组 - 全基因组研究的研究（n = 1145年的年轻人）的基因和一项基因的研究（An n = 1145 Healthy necy Nation） 483名健康的年轻人的独立样本检查了任何鉴定出的基因对脑功能的影响。不报告TTLL11对ADHD的小但统计学上的显着影响，复制了TTLL11基因与静止状态的活性和体体网络的连通性有关，并且可以通过较低的脑网络连接来预测躯体网络的连通性。等位基因载体表达数据库表明，该基因的表达富含大脑，而G等位基因与A等位基因相比较低的表达水平。
TLL11与持续关注的基因组范围内的重要关联。
TTLL11对注意缺陷/多动症（ADHD）的显着影响已在两个ADHD基因组的关联研究结果中得到证实。
TTLL11调节了大脑活动与持续关注之间的关联。
Genetic studies on attention have mainly focused on children with attention‐deficit/hyperactivity disorder (ADHD), so little systematic research has been conducted on genetic correlates of attention performance and their potential brain mechanisms among healthy individuals. The current study included a genome‐wide association study (GWAS, N = 1145 healthy young adults) aimed to identify genes associated with sustained attention and an imaging genetics study (an independent sample of 483 healthy young adults) to examine any identified genes' influences on brain function. The GWAS found that TTLL11 showed genome‐wide significant associations with sustained attention, with rs13298112 as the most significant SNP and the GG homozygotes showing more impulsive but also more focused responses than the A allele carriers. A retrospective examination of previously published ADHD GWAS results confirmed an un‐reported, small but statistically significant effect of TTLL11 on ADHD. The imaging genetics study replicated this association and showed that the TTLL11 gene was associated with resting state activity and connectivity of the somatomoter network, and can be predicted by dorsal attention network connectivity. Specifically, the GG homozygotes showed lower brain activity, weaker brain network connectivity, and non‐significant brain‐attention association compared to the A allele carriers. Expression database showed that expression of this gene is enriched in the brain and that the G allele is associated with lower expression level than the A allele. These results suggest that TTLL11 may play a major role in healthy individuals' attention performance and may also contribute to the etiology of ADHD. TLL11 showed genome‐wide significant associations with sustained attention. The significant effect of TTLL11 on attention‐deficit/hyperactivity disorder (ADHD) was confirmed in two ADHD genome‐wide association study results. TTLL11 modulated the association between brain activity and sustained attention.
登录
查看更多内容
探索患有注意力缺陷/多动症的儿童的白质功能网络。
影响因子：
4.8
作者：
Bu X;Liang K;Lin Q;Gao Y;Qian A;Chen H;Chen W;Wang M;Yang C;Huang X
通讯作者：
Huang X
影响因子：
14.9
作者：
Dougherty JD;Schmidt EF;Nakajima M;Heintz N
通讯作者：
Heintz N
注意力缺陷多动障碍的遗传学。
影响因子：
11
作者：
Faraone SV;Larsson H
通讯作者：
Larsson H
影响因子：
30.8
作者：
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者：
Neale, Benjamin M.
人脑网络组图谱：基于连接架构的新大脑图谱
DOI：
10.1093/cercor/bhw157
发表时间：
2016-08
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Fan L;Li H;Zhuo J;Zhang Y;Wang J;Chen L;Yang Z;Chu C;Xie S;Laird AR;Fox PT;Eickhoff SB;Yu C;Jiang T
通讯作者：
Jiang T