Exploring white matter functional networks in children with attention-deficit/hyperactivity disorder.
Exploring white matter functional networks in children with attention-deficit/hyperactivity disorder.
复制标题
探索患有注意力缺陷/多动症的儿童的白质功能网络。
DOI：
10.1093/braincomms/fcaa113
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发表时间：
2020
影响因子：
4.8
通讯作者：
Huang X
中科院分区：
文献类型：
--
作者：
Bu X;Liang K;Lin Q;Gao Y;Qian A;Chen H;Chen W;Wang M;Yang C;Huang X
注意力缺陷/多动障碍已被确定为涉及灰质内大规模功能网络的损伤，最近的研究表明，也编码神经活动的白色物质可以表现出与灰质相似的内在功能组织。然而，注意力缺陷多动障碍患者的白色物质功能网络的改变仍不清楚。我们共招募了99名儿童，包括66名未接受药物治疗的患者和33名年龄在6至14岁的正常对照，以描述未接受药物治疗的注意缺陷/多动障碍儿童白色物质内功能网络的改变。使用聚类分析，在白色物质的静息态功能磁共振成像数据被解析到不同的网络。评估每个网络内的内在活动和网络之间的连接以及网络活动强度与临床症状之间的关联。我们确定了八个不同的白色物质功能网络：默认模式网络，躯体运动网络，背侧注意网络，腹侧注意网络，视觉网络，深额顶网络，深额叶网络和下皮质脊髓后小脑网络。默认模式，躯体运动，背侧注意和腹侧注意网络显示较低的自发神经活动的患者。特别是，默认模式网络和躯体运动网络在很大程度上表现出与其他网络的较高连接性，这与更严重的多动行为相关，而背侧和腹侧注意网络主要与其他网络的连接性较低，这与注意力表现较差相关。总之，注意缺陷多动障碍儿童的白色物质功能网络存在两种不同的模式，一种是多动相关的热网络，包括默认模式网络和躯体运动网络;另一种是不注意相关的冷网络，包括背侧注意和腹侧注意网络。这些结果从白色功能障碍的角度扩展了我们对注意缺陷多动障碍脑功能网络的理解。注意缺陷多动障碍儿童的白色功能网络有两种不同的模式。一种是与多动行为相关的热网络，包括默认模式网络和躯体运动网络;另一种是与不注意相关的冷网络，包括背侧注意网络和腹侧注意网络。
Attention-deficit/hyperactivity disorder has been identified to involve the impairment of large-scale functional networks within grey matter, and recent studies have suggested that white matter, which also encodes neural activity, can manifest intrinsic functional organization similar to that of grey matter. However, the alterations in white matter functional networks in attention-deficit/hyperactivity disorder remain unknown. We recruited a total of 99 children, including 66 drug-naive patients and 33 typically developing controls aged from 6 to 14, to characterize the alterations in functional networks within white matter in drug-naive children with attention-deficit/hyperactivity disorder. Using clustering analysis, resting-state functional MRI data in the white matter were parsed into different networks. Intrinsic activity within each network and connectivity between networks and the associations between network activity strength and clinical symptoms were assessed. We identified eight distinct white matter functional networks: the default mode network, the somatomotor network, the dorsal attention network, the ventral attention network, the visual network, the deep frontoparietal network, the deep frontal network and the inferior corticospinal-posterior cerebellum network. The default mode, somatomotor, dorsal attention and ventral attention networks showed lower spontaneous neural activity in patients. In particular, the default mode network and the somatomotor network largely showed higher connectivity with other networks, which correlated with more severe hyperactive behaviour, while the dorsal and ventral attention networks mainly had lower connectivity with other networks, which correlated with poor attention performance. In conclusion, there are two distinct patterns of white matter functional networks in children with attention-deficit/hyperactivity disorder, with one being the hyperactivity-related hot networks including default mode network and somatomotor network and the other being inattention-related cold networks including dorsal attention and ventral attention network. These results extended upon our understanding of brain functional networks in attention-deficit/hyperactivity disorder from the perspective of white matter dysfunction. There are two distinct patterns of white matter functional networks in children with attention-deficit/hyperactivity disorder. One is the hyperactive behaviour-related hot networks including default mode network and somatomotor network, and the other is inattention-related cold networks including dorsal attention and ventral attention network.
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影响因子：
10.6
作者：
Fair, Damien A.;Posner, Jonathan;Nagel, Bonnie J.;Bathula, Deepti;Dias, Taciana G. Costa;Mills, Kathryn L.;Blythe, Michael S.;Giwa, Aishat;Schmitt, Colleen F.;Nigg, Joel T.
通讯作者：
Nigg, Joel T.
影响因子：
4.8
作者：
Li, Jiao;Biswal, Bharat B.;Liao, Wei
通讯作者：
Liao, Wei
影响因子：
4.8
作者：
de Lacy N;Kodish I;Rachakonda S;Calhoun VD
通讯作者：
Calhoun VD
影响因子：
4.8
作者：
Carmona, Susana;Hoekzema, Elseline;Castellanos, Francisco X.;Garcia-Garcia, David;Lage-Castellanos, Agustin;Van Dijk, Koene R. A.;Navas-Sanchez, Francisco J.;Martinez, Kenia;Desco, Manuel;Sepulcre, Jorge
通讯作者：
Sepulcre, Jorge
影响因子：
81.5
作者：
Faraone, Stephen V.;Asherson, Philip;Franke, Barbara
通讯作者：
Franke, Barbara