Performance evaluation of an Inveon PET preclinical scanner.
Performance evaluation of an Inveon PET preclinical scanner.
复制标题
DOI：
10.1088/0031-9155/54/9/020
复制
发表时间：
2009-05-07
影响因子：
3.5
通讯作者：
Mukherjee J
中科院分区：
文献类型：
--
作者：
Constantinescu CC;Mukherjee J
我们评估了Inveon临床前PET扫描仪（Siemens Medical Solutions）的性能，这是最新的MicroPET系统。用填充有18F溶液的玻璃毛细管（内径0.26 mm，壁厚0.29 mm）测量空间分辨率。横轴和轴向分辨率的测量与源放置平行和垂直于扫描仪的轴。扫描仪的灵敏度是用22 Na点源测量的，该点源放置在动物床上并定位在距视场（FOV）中心的不同偏移处，以及在不同的能量和符合窗口处。用大鼠（Φ = 60，L = 150 mm）和小鼠（Φ = 25 mm，L = 70 mm）圆柱体模型测量噪声等效计数率（NECR）和系统散射分数。填充有高活性18F（>250 MBq）的线源平行于体模的轴（13.5和10 mm偏移）插入。对于每个体模，在350-650 keV和250-750 keV能量窗口和3.4 ns符合窗口下收集24 h的列表模式数据。当随机事件发生率低于1%时，测量系统散射分数。对由具有填充有18F的热棒插入物的圆柱体组成的性能模型进行成像。此外，我们进行了成像研究，显示了Inveon扫描仪用于成像小结构的适用性，例如具有各种示踪剂的小鼠。视场中心的径向、切向和轴向分辨率分别为1.46 mm、1.49 mm和1.15 mm。在径向偏移为2 cm时，FWHM值分别为1.73、2.20和1.47 mm。在符合窗口为3.4ns时，EW = 350-650 keV的灵敏度为5.75%，EW = 250-750 keV的灵敏度为7.4%。对于350-650 keV的能量窗口，大鼠样体模在131.4 MBq处的峰值NECR为538 kcps，小鼠样体模在147.4 MBq处的峰值NECR为1734 kcps。大鼠体模的系统散射分数值为0.22，小鼠体模的系统散射分数值为0.06。Inveon系统具有高图像分辨率、低散射分数值以及改进的灵敏度和计数率性能。
We evaluated the performance of an Inveon preclinical PET scanner (Siemens Medical Solutions), the latest MicroPET system. Spatial resolution was measured with a glass capillary tube (0.26 mm inside diameter, 0.29 mm wall thickness) filled with 18F solution. Transaxial and axial resolutions were measured with the source placed parallel and perpendicular to the axis of the scanner. The sensitivity of the scanner was measured with a 22Na point source, placed on the animal bed and positioned at different offsets from the center of the field of view (FOV), as well as at different energy and coincidence windows. The noise equivalent count rates (NECR) and the system scatter fraction were measured using rat-like (Φ = 60, L = 150 mm) and mouse-like (Φ = 25 mm, L = 70 mm) cylindrical phantoms. Line sources filled with high activity 18F (>250 MBq) were inserted parallel to the axes of the phantoms (13.5 and 10 mm offset). For each phantom, list-mode data were collected over 24 h at 350–650 keV and 250–750 keV energy windows and 3.4 ns coincidence window. System scatter fraction was measured when the random event rates were below 1%. Performance phantoms consisting of cylinders with hot rod inserts filled with 18F were imaged. In addition, we performed imaging studies that show the suitability of the Inveon scanner for imaging small structures such as those in mice with a variety of tracers. The radial, tangential and axial resolutions at the center of FOV were 1.46 mm, 1.49 and 1.15 mm, respectively. At a radial offset of 2 cm, the FWHM values were 1.73, 2.20 and 1.47 mm, respectively. At a coincidence window of 3.4 ns, the sensitivity was 5.75% for EW = 350–650 keV and 7.4% for EW = 250–750 keV. For an energy window of 350–650 keV, the peak NECR was 538 kcps at 131.4 MBq for the rat-like phantom, and 1734 kcps at 147.4 MBq for the mouse-like phantom. The system scatter fraction values were 0.22 for the rat phantom and 0.06 for the mouse phantom. The Inveon system presents high image resolution, low scatter fraction values and improved sensitivity and count rate performance.
登录
查看更多内容
DOI：
10.1007/bf02258426
发表时间：
1991-06-01
期刊：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
影响因子：
--
作者：
BAILEY, DL;JONES, T;SPINKS, TJ
通讯作者：
SPINKS, TJ
影响因子：
--
作者：
Vaquero, J J;Desco, M
通讯作者：
Desco, M
影响因子：
9.3
作者：
Kim, Jin Su;Lee, Jae Sung;Moon, Dae Hyuk
通讯作者：
Moon, Dae Hyuk
影响因子：
3.5
作者：
Tai, YC;Chatziioannou, AF;Cherry, SR
通讯作者：
Cherry, SR
影响因子：
1.8
作者：
Laforest, Richard;Longford, Desmond;Yap, Jeffrey
通讯作者：
Yap, Jeffrey