Cancer and developmental exposure to endocrine disruptors.
Cancer and developmental exposure to endocrine disruptors.
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DOI：
10.1289/ehp.5686
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发表时间：
2003-04
影响因子：
10.4
通讯作者：
Fenton SE
中科院分区：
文献类型：
--
作者：
Birnbaum LS;Fenton SE
发育中的生物如果在快速生长和分化过程中暴露于环境毒物，则会增加对癌症的易感性。人类研究表明，产前暴露于电离辐射后，癌症明显增加，并且有证据表明，脑瘤和白血病与父母暴露于化学物质有关。动物实验表明，产前或新生儿接触各种化学物质，包括直接作用的致癌物质和药物，会导致肿瘤形成增加。最近，天然雌激素已被列为已知的人类致癌物。产前暴露于天然和合成雌激素与人类乳腺和阴道肿瘤以及动物子宫肿瘤的增加有关。合成卤化化学品在生命早期暴露后会增加肝脏肿瘤。最近，一个典型的内分泌干扰化合物，2，3，7，8-四氯二苯并-p-二恶英，已被证明是一个发育毒物的乳腺在啮齿动物。二恶英会改变多个内分泌系统，其对发育中的乳腺的影响包括乳腺的增殖和分化延迟，以及对潜在致癌物敏感窗口的延长。这些新发现的意义表明，内分泌相关癌症或癌症易感性的原因可能是发育暴露的结果，而不是在肿瘤检测时或接近检测时存在的暴露。
Developing organisms have increased susceptibility to cancer if they are exposed to environmental toxicants during rapid growth and differentiation. Human studies have demonstrated clear increases in cancer after prenatal exposure to ionizing radiation, and there is suggestive evidence that brain tumors and leukemia are associated with parental exposures to chemicals. Animal experiments have demonstrated increased tumor formation induced by prenatal or neonatal exposure to a variety of chemicals, including direct-acting carcinogens and drugs. Recently, natural estrogens have been classified as known human carcinogens. Prenatal exposure to natural and synthetic estrogens is associated with increases in breast and vaginal tumors in humans as well as uterine tumors in animals. Synthetic halogenated chemicals increase liver tumors after early life-stage exposure. Recently, a prototypical endocrine-disrupting compound, 2,3,7,8-tetrachlorodibenzo-p-dioxin, has been shown to be a developmental toxicant of the mammary gland in rodents. Dioxin alters multiple endocrine systems, and its effects on the developing breast involve delayed proliferation and differentiation of the mammary gland, as well as an elongation of the window of sensitivity to potential carcinogens. Implications of these new findings suggest that causes of endocrine-related cancers or susceptibility to cancer may be a result of developmental exposures rather than exposures existing at or near the time of tumor detection.
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二恶英毒性的机制：与风险评估的关系。
影响因子：
10.4
作者：
Birnbaum, L S
通讯作者：
Birnbaum, L S
DOI：
10.1080/026520300283351
发表时间：
2000-04-01
影响因子：
2.9
作者：
Birnbaum, LS;Tuomisto, J
通讯作者：
Tuomisto, J
影响因子：
3.8
作者：
Flaws, JA;Sommer, RJ;Hirshfield, AN
通讯作者：
Hirshfield, AN
影响因子：
3.8
作者：
Fenton, SE;Hamm, JT;Youngblood, GL
通讯作者：
Youngblood, GL
DOI：
10.1016/0272-0590(92)90139-9
发表时间：
1992-04-01
期刊：
FUNDAMENTAL AND APPLIED TOXICOLOGY
影响因子：
--
作者：
CHHABRA, RS;EUSTIS, S;CARLTON, BD
通讯作者：
CARLTON, BD