Dendritic Integration of Sensory Evidence in Perceptual Decision-Making.
Dendritic Integration of Sensory Evidence in Perceptual Decision-Making.
复制标题
DOI：
10.1016/j.cell.2018.03.075
复制
发表时间：
2018-05-03
期刊：
影响因子：
64.5
通讯作者：
Miesenböck G
中科院分区：
文献类型：
--
作者：
Groschner LN;Chan Wah Hak L;Bogacz R;DasGupta S;Miesenböck G
知觉决策需要积累符合反应标准的感觉信息。大多数关于大脑如何执行这一时间整合过程的描述都集中在尖峰活动的演变模式上。我们报告，膜电压的亚阈值变化可以代表在选择之前积累的证据。果蝇蘑菇体中的αβ核心凯尼恩细胞(αβc KCs)在与嗅觉识别速度相匹配的时间尺度上将气味诱发的突触输入整合到动作电位阈值。叉头盒P转录因子(FOXP)通过控制αβc KC树突中电压门控钾通道Shal(KV4)的丰度来设定神经元整合和行为决定时间。因此，αβc KCs通过生物物理属性的特定星座来定制突触整合的一般过程，以满足顺序采样的要求。突触整合可以实现一个有限度的证据积累过程，FoxP在αβc-Kenyon细胞(KCs)中发挥作用，抑制电压门控钾通道Shal Shal调节αβc-KCs随着时间推移求和突触输入的能力，改变αβc-KCs中的Shal电流，改变尖峰潜伏期和决策时间，信息是如何整合以允许感知决策？果蝇中表达FoxP的神经元随着亚阈值电压的变化而积累感觉证据。第一个峰值标志着一个决定。
Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accumulating evidence before a choice. αβ core Kenyon cells (αβc KCs) in the mushroom bodies of fruit flies integrate odor-evoked synaptic inputs to action potential threshold at timescales matching the speed of olfactory discrimination. The forkhead box P transcription factor (FoxP) sets neuronal integration and behavioral decision times by controlling the abundance of the voltage-gated potassium channel Shal (KV4) in αβc KC dendrites. αβc KCs thus tailor, through a particular constellation of biophysical properties, the generic process of synaptic integration to the demands of sequential sampling. Synaptic integration can implement a process of bounded evidence accumulation FoxP acts in αβc Kenyon cells (KCs) to repress the voltage-gated potassium channel Shal Shal regulates the ability of αβc KCs to summate synaptic inputs over time Altering Shal currents in αβc KCs changes spike latencies and decision times How is information integrated to allow perceptual decision-making? FoxP-expressing neurons in fruit flies accumulate sensory evidence as subthreshold voltage changes. The first spike signals that a decision.
登录
查看更多内容
影响因子：
7.7
作者：
Aso Y;Hattori D;Yu Y;Johnston RM;Iyer NA;Ngo TT;Dionne H;Abbott LF;Axel R;Tanimoto H;Rubin GM
通讯作者：
Rubin GM
影响因子：
25
作者：
Gruntman, Eyal;Turner, Glenn C.
通讯作者：
Turner, Glenn C.
影响因子：
16.2
作者：
Hige T;Aso Y;Modi MN;Rubin GM;Turner GC
通讯作者：
Turner GC
影响因子：
9.8
作者：
Hamdan, Fadi F.;Daoud, Hussein;Michaud, Jacques L.
通讯作者：
Michaud, Jacques L.
影响因子：
7.7
作者：
Aso Y;Sitaraman D;Ichinose T;Kaun KR;Vogt K;Belliart-Guérin G;Plaçais PY;Robie AA;Yamagata N;Schnaitmann C;Rowell WJ;Johnston RM;Ngo TT;Chen N;Korff W;Nitabach MN;Heberlein U;Preat T;Branson KM;Tanimoto H;Rubin GM
通讯作者：
Rubin GM