From tumor microenvironment communicants to biomarker discovery: Selectively packaged extracellular vesicular cargoes in pancreatic cancer.
From tumor microenvironment communicants to biomarker discovery: Selectively packaged extracellular vesicular cargoes in pancreatic cancer.
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DOI：
10.1016/j.cytogfr.2020.01.001
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发表时间：
2020-03
影响因子：
13
通讯作者：
Hughes SJ
中科院分区：
文献类型：
--
作者：
Han S;Underwood P;Hughes SJ
几乎所有细胞都会将各种类型的囊泡释放到细胞外环境中。这些细胞外囊泡 (EV) 运输分子货物，充当肿瘤微环境 (TME) 内和远处器官信息交换的通讯者。因此，了解 EV 货物的选择性包装以及这些货物（包括代谢物、脂质、蛋白质和/或核酸）的机械影响，为增加我们对癌症生物学的了解并识别可能作为血液、唾液或尿液样本中的癌症生物标志物的 EV 货物提供了机会。在这篇综述中，我们收集并整理了该领域的最新进展，重点是胰腺癌（胰腺腺癌，PDAC）以及细胞选择性地将货物包装到 EV 中的概念。这些研究表明 PDAC EV 货物信号可以重新编程和重塑 TME 并影响远处的器官。总结了被确定为潜在 PDAC 诊断和预后生物标志物的 EV 货物。
Virtually all cells release various types of vesicles into the extracellular environment. These extracellular vesicles (EVs) transport molecular cargoes, performing as communicants for information exchange both within the tumor microenvironment (TME) and to distant organs. Thus, understanding the selective packaging of EV cargoes and the mechanistic impact of those cargoes - including metabolites, lipids, proteins, and/or nucleic acids - offers an opportunity to increase our knowledge of cancer biology and identify EV cargoes that might serve as cancer biomarkers in blood, saliva, or urine samples. In this review, we collect and organize recent advances in this field with an emphasis on pancreatic cancer (pancreatic adenocarcinoma, PDAC) and the concept that cells selectively package cargo into EVs. These studies demonstrate PDAC EV cargoe signals to reprogram and remodel the TME and impact distant organs. EV cargoes identified as potential PDAC diagnostic and prognostic biomarkers are summarized.
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