Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women.
Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women.
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催产素与安慰剂对侵入性记忆巩固的影响使用创伤膜范式：健康女性的一项随机，受控的实验研究。
DOI：
10.1038/s41398-023-02339-z
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发表时间：
2023-02-04
影响因子：
6.8
通讯作者：
Roepke, Stefan
中科院分区：
文献类型：
--
作者：
Maslahati, Tolou;Wingenfeld, Katja;Hellmann-Regen, Julian;Kraft, Julia;Lyu, Jing;Keinert, Marie;Voss, Aline;Cho, An Bin;Ripke, Stephan;Otte, Christian;Schultebraucks, Katharina;Roepke, Stefan
研究表明，在创伤模拟过程中使用催产素可以增加侵入性记忆，这是创伤后应激障碍(PTSD)的核心症状。然而，催产素是否影响创伤的获得或巩固尚不清楚。本研究探讨了模拟创伤巩固过程中催产素系统的激活对连续四天的侵入式记忆形成的影响，以及这种影响是否受个体神经生物学、遗传或心理因素的影响。我们对217名健康女性进行了一项随机、双盲、安慰剂对照研究。他们在接触创伤电影范例后，接受了单剂量的鼻腔催产素(24IU)或安慰剂，这可以可靠地诱导侵入性记忆。我们使用一个普通的随机森林来检验催产素对侵入性记忆巩固的潜在的异质治疗效果。此外，我们使用泊松回归来检验唾液α淀粉酶活性(SAA)作为去甲肾上腺素能活动和皮质醇对电影的反应的标志，精神障碍的多基因风险评分(PRS)，以及心理因素是否影响侵入性记忆的数量。我们发现催产素对侵袭性记忆的形成没有显著影响(F(2,543.16) = 0.75，p = 0.51，ηp2 = 0.00)，也没有发现异质性处理效应。我们复制了之前创伤后应激障碍、SaA和皮质醇反应与侵入性记忆之间的联系。我们进一步发现，高特质焦虑与侵入式记忆呈正相关，而情绪调节策略再评价与侵入式记忆呈负相关。本研究的数据表明，女性侵入性记忆的巩固受遗传、神经生物学和心理因素的调节，但不受催产素的影响。试用登记：NCT03875391。
Oxytocin administration during a trauma analogue has been shown to increase intrusive memories, which are a core symptom of post-traumatic stress disorder (PTSD). However, it is unknown whether oxytocin influences the acquisition or the consolidation of the trauma. The current study investigates the effect of the activation of the oxytocin system during the consolidation of an analogue trauma on the formation of intrusive memories over four consecutive days and whether this effect is influenced by individual neurobiological, genetic, or psychological factors. We conducted a randomized double-blind placebo-controlled study in 217 healthy women. They received either a single dose of intranasal oxytocin (24 IU) or placebo after exposure to a trauma film paradigm, which reliably induces intrusive memories. We used a general random forest to examine a potential heterogeneous treatment effect of oxytocin on the consolidation of intrusive memories. Furthermore, we used a poisson regression to examine whether salivary alpha amylase activity (sAA) as a marker of noradrenergic activity and cortisol response to the film, polygenic risk score (PRS) for psychiatric disorders, and psychological factors influence the number of intrusive memories. We found no significant effect of oxytocin on the formation of intrusive memories (F(2, 543.16) = 0.75, p = 0.51, ηp2 = 0.00) and identified no heterogeneous treatment effect. We replicated previous associations of the PRS for PTSD, sAA and the cortisol response on intrusive memories. We further found a positive association between high trait anxiety and intrusive memories, and a negative association between the emotion regulation strategy reappraisal and intrusive memories. Data of the present study suggest that the consolidation of intrusive memories in women is modulated by genetic, neurobiological and psychological factors, but is not influenced by oxytocin. Trial registration: NCT03875391.
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影响因子：
4.5
作者：
Athey, Susan;Tibshirani, Julie;Wager, Stefan
通讯作者：
Wager, Stefan
影响因子：
2.4
作者：
Ferree, Nikole K.;Kamat, Rujvi;Cahill, Larry
通讯作者：
Cahill, Larry
具有和没有PTSD的战斗暴露的退伍军人的认知重新评估使用和情绪调节大脑功能的个体差异。
影响因子：
7.4
作者：
Fitzgerald JM;MacNamara A;Kennedy AE;Rabinak CA;Rauch SA;Liberzon I;Phan KL
通讯作者：
Phan KL
影响因子：
3.3
作者：
Weber, Heike;Maihofer, Adam X.;Jaksic, Nenad;Bojic, Elma Feric;Kucukalic, Sabina;Dzananovic, Emina Sabic;Uka, Aferdita Goci;Hoxha, Blerina;Haxhibeqiri, Valdete;Haxhibeqiri, Shpend;Kravic, Nermina;Umihanic, Mirnesa Muminovic;Franc, Ana Cima;Babic, Romana;Pavlovic, Marko;Mehmedbasic, Alma Bravo;Aukst-Margetic, Branka;Kucukalic, Abdulah;Marjanovic, Damir;Babic, Dragan;Bozina, Nada;Jakovljevic, Miro;Sinanovic, Osman;Avdibegovic, Esmina;Agani, Ferid;Warrings, Bodo;Domschke, Katharina;Nievergelt, Caroline M.;Deckert, Juergen;Dzubur-Kulenovic, Alma;Erhardt, Angelika
通讯作者：
Erhardt, Angelika
影响因子：
4.2
作者：
Aase, Darrin M.;Gorka, Stephanie M.;Luan Phan, K.
通讯作者：
Luan Phan, K.