Increased tissue-level storage modulus and hardness with age in male cortical bone and its association with decreased fracture toughness.
Increased tissue-level storage modulus and hardness with age in male cortical bone and its association with decreased fracture toughness.
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DOI：
10.1016/j.bone.2021.115949
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发表时间：
2021-07
期刊：
影响因子：
4.1
通讯作者：
Nyman JS
中科院分区：
文献类型：
--
作者：
Singleton RC;Pharr GM;Nyman JS
骨折的发生率随着年龄的增长而增加，这是由于骨的数量和质量都在下降。为了更好地了解男性皮质骨断裂韧性随年龄增长而下降的原因，对21-98岁男性股骨干标本进行了纳米压痕实验。由于老年骨具有较少的基质结合水和干燥骨是粘弹性较低，我们使用了纳米压痕法，是敏感的粘弹性的变化。考虑到骨刚度的各向异性，对相对于股骨干长轴的纵向（n = 26）和横向（n = 25）样本进行了空气干燥和磷酸盐缓冲盐水溶液浸泡试验。压痕刚度（储能模量）和硬度随着年龄的增长，而粘弹性（损耗模量）是独立的供体年龄。压痕刚度和硬度随年龄的增加，最好的解释增加矿化与年龄。压痕刚度和硬度与先前获得的断裂韧性参数呈负相关，这与材料强度和韧性之间的权衡一致。与骨的复杂结构一致，回归模型中的组织水平储能模量或硬度、结合水和骨细胞面积的组合最好地解释了男性皮质骨断裂韧性的变化。另一方面，粘弹性是不变的，随着年龄的增长，并没有与断裂韧性。总之，男性皮质骨刚度和硬度的年龄相关性增加可能是导致断裂韧性降低的多个组织水平特征之一。
The incidence of bone fracture increases with age, due to both declining bone quantity and quality. Towards the goal of an improved understanding of the causes of the age-related decline in the fracture toughness of male cortical bone, nanoindentation experiments were performed on femoral diaphysis specimens from men aged 21–98 years. Because aged bone has less matrix-bound water and dry bone is less viscoelastic, we used a nanoindentation method that is sensitive to changes in viscoelasticity. Given the anisotropy of bone stiffness, longitudinal (n = 26) and transverse (n = 25) specimens relative to the long axis of the femur diaphysis were tested both dry in air and immersed in phosphate buffered saline solution. Indentation stiffness (storage modulus) and hardness increased with age, while viscoelasticity (loss modulus) was independent of donor age. The increases in indentation stiffness and hardness with age were best explained by increased mineralization with age. Indentation stiffness and hardness were negatively correlated with previously acquired fracture toughness parameters, which is consistent with a tradeoff between material strength and toughness. In keeping with the complex structure of bone, a combination of tissue-level storage modulus or hardness, bound water, and osteonal area in regression models best explained the variance in the fracture toughness of male human cortical bone. On the other hand, viscoelasticity was unchanged with age and was not associated with fracture toughness. In conclusion, the age-related increase in stiffness and hardness of male cortical bone may be one of the multiple tissue-level characteristics that contributes to decreased fracture toughness.
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影响因子：
4.1
作者：
Katsamenis, Orestis L.;Jenkins, Thomas;Thurner, Philipp J.
通讯作者：
Thurner, Philipp J.
影响因子：
4.1
作者：
Malo, M. K. H.;Rohrbach, D.;Raum, K.
通讯作者：
Raum, K.
影响因子：
2.4
作者：
Hofmann, Tobias;Heyroth, Frank;Raum, Kay
通讯作者：
Raum, Kay
影响因子：
2.8
作者：
Hoffler, CE;Moore, KE;Goldstein, SA
通讯作者：
Goldstein, SA
DOI：
10.1016/j.msec.2005.08.021
发表时间：
2006-09-01
期刊：
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
影响因子：
--
作者：
Nalla, R. K.;Kruzic, J. J.;Ritchie, R. O.
通讯作者：
Ritchie, R. O.