The diverse origin of bone-forming osteoblasts.
The diverse origin of bone-forming osteoblasts.
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DOI：
10.1002/jbmr.4410
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Ono N
中科院分区：
文献类型：
--
作者：
Mizoguchi T;Ono N
成骨细胞是脊椎动物中唯一能产生骨骼的细胞。因此，这些代谢活性细胞最重要的功能之一是矿化基质的产生。由于成骨细胞的寿命有限，它们必须不断地由前成骨细胞（它们的直接前体）补充。由于成骨细胞的调节被破坏导致各种骨疾病，通过定义骨发育、重塑、再生的机制来更好地理解这些细胞的起源对于开发新的治疗方法至关重要。近年来，大量的新见解成骨细胞的起源-主要是由于在小鼠谱系追踪方法和其他单细胞技术的快速技术进步-已经获得。总的来说，这些发现表明，在各种生理、病理和治疗条件下参与骨形成的成骨细胞可以从许多来源获得。成骨细胞的来源包括但不限于生长板中的软骨细胞、骨髓中的基质细胞、骨表面上的静止骨衬细胞和颅面结构（如缝合线和牙周韧带）中的特化成纤维细胞。由于成骨细胞可以从局部细胞来源产生，骨骼可以灵活地对再生和合成代谢信号做出反应。然而，不同细胞来源的成骨细胞是否具有不同的功能仍有待研究。目前，我们正处于初步阶段，以适当地解开骨形成成骨细胞的起源令人难以置信的多样性。
Osteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of the most important functions of these metabolically active cells is mineralized matrix production. As osteoblasts have a limited lifespan, they must be constantly replenished by pre-osteoblasts, their immediate precursors. As disruption of the regulation of bone-forming osteoblasts results in a variety of bone diseases, a better understanding of the origin of these cells by defining the mechanisms of bone development, remodeling, regeneration is central to the development of novel therapeutic approaches. In recent years, substantial new insights into the origin of osteoblasts – largely owing to rapid technological advances in murine lineage-tracing approaches and other single-cell technologies – have been obtained. Collectively, these findings indicate that osteoblasts involved in bone formation under various physiological, pathological, and therapeutic conditions can be obtained from numerous sources. The origins of osteoblasts include – but are not limited to – chondrocytes in the growth plate, stromal cells in the bone marrow, quiescent bone-lining cells on the bone surface, and specialized fibroblasts in the craniofacial structures, such as sutures and periodontal ligaments. As osteoblasts can be generated from local cellular sources, bones can flexibly respond to regenerative and anabolic cues. However, whether osteoblasts derived from different cellular sources have distinct functions remains to be investigated. Currently, we are at the initial stage to aptly unravel the incredible diversity of the origins of bone-forming osteoblasts.
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影响因子：
64.5
作者：
Baryawno, Ninib;Przybylski, Dariusz;Scadden, David T.
通讯作者：
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通讯作者：
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DOI：
10.1073/pnas.0504750102
发表时间：
2005-10-11
影响因子：
11.1
作者：
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通讯作者：
de Crombrugghe, B