Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis.
Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis.
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DOI：
10.1007/s12017-013-8262-x
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发表时间：
2013-12
影响因子：
3.5
通讯作者：
Trotti, Davide
中科院分区：
文献类型：
--
作者：
Foran, Emily;Rosenblum, Lauren;Bogush, Alexey I.;Trotti, Davide
关键词：
Emerging lines of evidence suggest a relationship between amyotrophic lateral sclerosis (ALS) and protein sumoylation. Multiple studies have demonstrated that several of the proteins involved in the pathogenesis of ALS, including superoxide dismutase 1 (SOD1), fused in liposarcoma (FUS), and TAR DNA binding protein 43 (TDP43), are substrates for sumoylation. Additionally, recent studies in cellular and animal models of ALS revealed that sumoylation of these proteins impact their localization, longevity and how they functionally perform in disease, providing novel areas for mechanistic investigations and therapeutics. In this article, we summarize the current literature examining the impact of sumoylation of critical proteins involved in ALS and discuss the potential impact for the pathogenesis of the disease. In addition, we report and discuss the implications of new evidence demonstrating that sumoylation of a fragment derived from the proteolytic cleavage of the astroglial glutamate transporter, EAAT2, plays a direct role in downregulating the expression levels of full length EAAT2 by binding to a regulatory region of its promoter.
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DOI：
10.1111/j.1440-1789.2009.01091.x
发表时间：
2010-04
期刊：
Neuropathology : official journal of the Japanese Society of Neuropathology
影响因子：
--
作者：
Geser F;Lee VM;Trojanowski JQ
通讯作者：
Trojanowski JQ
影响因子：
3.5
作者：
Evans, M. C.;Couch, Y.;Turner, M. R.
通讯作者：
Turner, M. R.
DOI：
10.1016/j.bbrc.2006.06.092
发表时间：
2006-08-25
影响因子：
3.1
作者：
Fei, Erkang;Jia, Nali;Wang, Guanghui
通讯作者：
Wang, Guanghui
影响因子：
8.8
作者：
Chopra V;Quinti L;Kim J;Vollor L;Narayanan KL;Edgerly C;Cipicchio PM;Lauver MA;Choi SH;Silverman RB;Ferrante RJ;Hersch S;Kazantsev AG
通讯作者：
Kazantsev AG
影响因子：
21.1
作者：
Fushimi K;Long C;Jayaram N;Chen X;Li L;Wu JY
通讯作者：
Wu JY