Role of ART in imprinting disorders.
Role of ART in imprinting disorders.
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DOI：
10.1055/s-0032-1307417
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发表时间：
2012-04
影响因子：
2.7
通讯作者：
Layman LC
中科院分区：
文献类型：
--
作者：
Eroglu A;Layman LC
辅助生殖技术（ART）为世界各地数百万无子女夫妇提供了革命性的不孕症治疗。目前，抗逆转录病毒疗法占工业化国家每年出生人数的1%至3%，并继续迅速扩大。除了早产发生率增加外，这些技术被认为是安全的。然而，在过去的十年中发表的新证据表明，在ART受孕的儿童中，印记疾病的发病率增加。特别是，Beckwith-Wiedemann综合征（BWS），Angelman综合征（AS），Silver-Russell综合征和视网膜母细胞瘤的风险增加。相反，一些研究发现ART与BWS、AS、Prader-Willi综合征、短暂性新生儿糖尿病和视网膜母细胞瘤之间没有关联。ART方案的可变性和印记疾病的罕见性使确定ART和印记疾病发病率增加之间的因果关系变得复杂。然而，令人信服的动物研究的实验数据也表明，增加印记疾病和艺术之间的联系。需要进一步全面，适当的动力研究，以更好地解决艺术相关的印记疾病的风险程度。大型纵向研究对于评估ART不仅在围产期而且在成年期的长期影响尤为重要。一个重要的考虑因素是确定ART和印记疾病之间的关联是否实际上与程序或不孕症本身有关。
Assisted reproductive technologies (ART) offer revolutionary infertility treatments for millions of childless couples around the world. Currently, ART accounts for 1 to 3% of annual births in industrialized countries and continues to expand rapidly. Except for an increased incidence of premature births, these technologies are considered safe. However, new evidence published during the past decade has suggested an increased incidence of imprinting disorders in children conceived by ART. Specifically, an increased risk was reported for Beckwith-Wiedemann syndrome (BWS), Angelman syndrome (AS), Silver-Russell syndrome, and retinoblastoma. In contrast, some studies have found no association between ART and BWS, AS, Prader-Willi syndrome, transient neonatal diabetes mellitus, and retinoblastoma. The variability in ART protocols and the rarity of imprinting disorders complicate determining the causative relationship between ART and an increased incidence of imprinting disorders. Nevertheless, compelling experimental data from animal studies also suggest a link between increased imprinting disorders and ART. Further comprehensive, appropriately powered studies are needed to better address the magnitude of the risk for ART-associated imprinting disorders. Large longitudinal studies are particularly critical to evaluate long-term effects of ART not only during the perinatal period but also into adulthood. An important consideration is to determine if the implicated association between ART and imprinting disorders is actually related to the procedures or to infertility itself.
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影响因子：
10.5
作者：
Berger, Shelley L.;Kouzarides, Tony;Shilatifard, Ali
通讯作者：
Shilatifard, Ali
影响因子：
64.8
作者：
BARTOLOMEI, MS;ZEMEL, S;TILGHMAN, SM
通讯作者：
TILGHMAN, SM
影响因子：
64.5
作者：
Cavalli, G;Paro, R
通讯作者：
Paro, R
DOI：
10.1073/pnas.51.5.786
发表时间：
1964-01-01
影响因子：
11.1
作者：
ALLFREY, VG;FAULKNER, R;MIRSKY, AE
通讯作者：
MIRSKY, AE
影响因子：
3.6
作者：
Chuang, Jody C.;Jones, Peter A.
通讯作者：
Jones, Peter A.