Regulation of dietary choice by the decision-making circuitry.

Regulation of dietary choice by the decision-making circuitry.
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DOI:
10.1038/nn.3561
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发表时间:
2013-12
影响因子:
25
通讯作者:
Rangel, Antonio
Rangel, Antonio
中科院分区:
医学1区
文献类型:
--
作者:
Rangel, Antonio

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为了进一步理解大脑如何做出食物决定,有必要将两个尚未很好整合的领域的知识联合收割机结合起来:决策的神经计算基础和进食的稳态调节器。这篇综述从神经计算的角度整合了这两篇文献,重点描述了不同神经系统计算的变量以及它们如何影响饮食选择。我们强调了喂养决策的独特之处,代谢和内分泌因素影响决策电路的机制,为什么许多人很难做出健康的食物选择,以及肥胖流行病中的关键过程。
To advance our understanding of how the brain makes food decisions, it is essential to combine knowledge from two fields that have not yet been well integrated: the neuro-computational basis of decision-making and the homeostatic regulators of feeding. This Review integrates these two literatures from a neuro-computational perspective, with an emphasis in describing the variables computed by different neural systems and how they affect dietary choice. We highlight what is unique about feeding decisions, the mechanisms through which metabolic and endocrine factors affect the decision-making circuitry, why making healthy food choices is difficult for many people, and key processes at work in the obesity epidemic.
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