Reducing stroke burden through a targeted self-management intervention for reducing stroke risk factors in high-risk Ugandans: A protocol for a randomized controlled trial.
Reducing stroke burden through a targeted self-management intervention for reducing stroke risk factors in high-risk Ugandans: A protocol for a randomized controlled trial.
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通过有针对性的自我管理干预措施减轻中风负担，以减少高危乌干达人的中风风险因素：随机对照试验的协议。
DOI：
10.1371/journal.pone.0251662
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Sajatovic M
中科院分区：
文献类型：
--
作者：
Kaddumukasa M;Najjuma J;Mbalinda SN;Kaddumukasa MN;Nakibuuka J;Burant C;Moore S;Blixen C;Katabira ET;Sajatovic M
全球中风负担正在迅速增加。可改变的危险因素提供了进行干预的机会，针对高血压是撒哈拉以南非洲减少中风风险的一个关键可行目标。这个3个地点的随机对照试验建立在有希望的初步数据基础上。总共将招募246名乌干达成年人，随机分为实验干预组和强化治疗对照组。干预组参与者每周将接受六次分组形式的卒中风险降低自我管理培训，对照组将接受心血管风险信息。主要研究结果是在基线、13周、24周（6个月）测量收缩期血压。次要结局包括其他生物学和行为性中风危险因素。课程指导的自我管理目标管理干预（TEAM）计划预计将减轻乌干达的中风负担。ClinicalTrials.gov标识符：NCT04685408，注册于2020年12月28日。
Stroke burden is rapidly increasing globally. Modifiable risk factors offer an opportunity to intervene, and targeting hypertension is a key actionable target for stroke risk reduction in sub-Saharan Africa. This 3-site planned randomized controlled trial builds on promising preliminary data. A total of 246 Ugandan adults will be recruited randomized to experimental intervention vs. enhanced treatment control. Intervention participants will receive six weekly group-format stroke risk reduction self-management training sessions, and the controls will receive information on cardiovascular risk. The primary study outcome is systolic B.P. measured at baseline, 13-week, 24 weeks (6 months). Secondary outcomes include other biological and behavioral stroke risk factors. The curriculum-guided self-management TargetEd MAnageMent Intervention (TEAM) program is anticipated to reduce the stroke burden in Uganda. ClinicalTrials.gov identifier: NCT04685408, registered on 28 December 2020.
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