Mitral valve opening in the ovine heart.
Mitral valve opening in the ovine heart.
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绵羊心脏的二尖瓣开口。
DOI：
10.1152/ajpheart.1998.274.2.h552
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
IngelsJr,NB
中科院分区：
文献类型：
--
作者：
Karlsson,MO;Glasson,JR;Bolger,AF;Daughters,GT;Komeda,M;Foppiano,LE;Miller,DC;IngelsJr,NB
为了研究二尖瓣瓣叶和瓣环的三维尺寸、形状和运动，我们在7只绵羊的二尖瓣瓣环和瓣叶上手术连接了不透射线标记。恢复8天后，对动物进行镇静，并通过计算机分析双平面视频荧光照片（60/s）测量三维标记位置。我们发现，卵圆形的二尖瓣环在二尖瓣中段变得最椭圆。在瓣叶边缘分离之前，在左心室压力（LVP）快速下降期间，两个瓣叶开始下降到左心室（LV）中。前叶在收缩期表现出复合弯曲，并在开放期间保持这种形状。在打开过程中，后叶的中央瓣尖略微弯曲，凹向LV。在心脏收缩期间，“粗糙区”边界处的标记间隔10 mm。我们得出结论，接合发生在非常靠近瓣叶边缘的位置，瓣环和瓣叶在LVP快速下降期间向其开放位置移动，瓣叶边缘分离（开放序列中的最后一个事件）发生在接近最小LVP的时间。
To study the three-dimensional size, shape, and motion of the mitral leaflets and annulus, we surgically attached radiopaque markers to sites on the mitral annulus and leaflets in seven sheep. After 8 days of recovery, the animals were sedated, and three-dimensional marker positions were measured by computer analysis of biplane videofluorograms (60/s). We found that the oval mitral annulus became most elliptical in middiastole. Both leaflets began to descend into the left ventricle (LV) during the rapid fall of LV pressure (LVP), before leaflet edge separation. The anterior leaflet exhibited a compound curvature in systole and maintained this shape during opening. The central cusp of the posterior leaflet was curved slightly concave to the LV during opening. Markers at the border of the “rough zone” were separated by 10 mm during systole. We conclude that coaptation occurs very near the leaflet edges, that the annulus and leaflets move toward their open positions during the rapid fall of LVP, and that leaflet edge separation, the last event in the opening sequence, occurs near the time of minimum LVP.
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影响因子：
20.1
作者：
R. F. Rushmer;Bliss L. Finlayson;Alden A. Nash
通讯作者：
Alden A. Nash
两个二尖瓣小叶的运动：完整狗的电影摄影研究。
影响因子：
3.3
作者：
A. Tsakiris;D. A. Gordon;Y. Mathieu;L. Irving
通讯作者：
L. Irving
影响因子：
37.8
作者：
LEVINE, RA;TRIULZI, MO;WEYMAN, AE
通讯作者：
WEYMAN, AE
影响因子：
37.8
作者：
LEVINE, RA;HANDSCHUMACHER, MD;WEYMAN, AE
通讯作者：
WEYMAN, AE
二尖瓣疾病。
影响因子：
4.2
作者：
B. Carabello
通讯作者：
B. Carabello