Lactate, a Neglected Factor for Diabetes and Cancer Interaction.
Lactate, a Neglected Factor for Diabetes and Cancer Interaction.
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DOI：
10.1155/2016/6456018
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发表时间：
2016
影响因子：
4.6
通讯作者：
Vadgama JV
中科院分区：
文献类型：
--
作者：
Wu Y;Dong Y;Atefi M;Liu Y;Elshimali Y;Vadgama JV
越来越多的证据表明，糖尿病和癌症之间存在联系。然而，迄今为止，这种关联的潜在原因仍然知之甚少，目前没有临床证据可用于指导伴发这两种疾病的患者的适当管理。癌症和糖尿病都与乳酸代谢异常有关，高水平的乳酸产生是这些疾病的关键生物学特性。相反，高乳酸导致更高的胰岛素抵抗状态和癌细胞更恶性的表型，促进糖尿病和癌症的发展和进展。鉴于糖尿病和癌症之间的关联，不应忽视高乳酸产生在糖尿病和癌症相互作用中的作用。本文综述了乳酸在糖尿病和癌症不同生物学特性中的作用及其相互关系。了解糖尿病和癌症相关信号代谢重塑背后的分子机制将为糖尿病和癌症治疗提供新的预防和治疗方法。
Increasing body of evidence suggests that there exists a connection between diabetes and cancer. Nevertheless, to date, the potential reasons for this association are still poorly understood and currently there is no clinical evidence available to direct the proper management of patients presenting with these two diseases concomitantly. Both cancer and diabetes have been associated with abnormal lactate metabolism and high level of lactate production is the key biological property of these diseases. Conversely, high lactate contribute to a higher insulin resistant status and a more malignant phenotype of cancer cells, promoting diabetes and cancer development and progression. In view of associations between diabetes and cancers, the role of high lactate production in diabetes and cancer interaction should not be neglected. Here, we review the available evidence of lactate's role in different biological characteristics of diabetes and cancer and interactive relationship between them. Understanding the molecular mechanisms behind metabolic remodeling of diabetes- and cancer-related signaling would endow novel preventive and therapeutic approaches for diabetes and cancer treatment.
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影响因子：
4.3
作者：
Berhane, Feven;Fite, Alemu;Seyoum, Berhane
通讯作者：
Seyoum, Berhane
影响因子：
--
作者：
Arcidiacono B;Iiritano S;Nocera A;Possidente K;Nevolo MT;Ventura V;Foti D;Chiefari E;Brunetti A
通讯作者：
Brunetti A
DOI：
10.1016/s0360-3016(01)01630-3
发表时间：
2001-10-01
影响因子：
7
作者：
Brizel, DM;Schroeder, T;Mueller-Klieser, W
通讯作者：
Mueller-Klieser, W
影响因子：
7.1
作者：
Barclay, Alan W.;Petocz, Peter;Brand-Miller, Jennie C.
通讯作者：
Brand-Miller, Jennie C.
影响因子：
4.3
作者：
Bonuccelli, Gloria;Tsirigos, Aristotelis;Lisanti, Michael P.
通讯作者：
Lisanti, Michael P.