Spread of a methicillin-resistant Staphylococcus aureus ST80 strain in the community of the northern Netherlands.

Spread of a methicillin-resistant Staphylococcus aureus ST80 strain in the community of the northern Netherlands.
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DOI:
10.1007/s10096-007-0352-y
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发表时间:
2007-10
影响因子:
4.5
通讯作者:
Moller, A. V. M.
Moller, A. V. M.
中科院分区:
医学3区
文献类型:
--
作者:
Stam-Bolink, E. M.;Mithoe, D.;Baas, W. H.;Arends, J. P.;Moller, A. V. M.

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由社区获得性耐甲氧西林金黄色葡萄球菌(MRSA)引起的感染正在成为一个主要的公共卫生问题。在这项研究中,我们描述了1998年至2005年之间在荷兰北方的54株携带Panton-Valentine杀白细胞素(PVL)的MRSA分离株的分布,其中43株(80%)由欧洲PVL阳性菌株多位点序列型80和葡萄球菌盒式染色体mec型IVc(ST 80)组成。ST 80的个体病例和小集群在社区中占主导地位(74%),但ST 80也在养老院(16%)和医院(9%)中发现。ST 80患者的长期携带(数月至数年)和再感染可能导致菌株在社区中传播,随后进一步迁移到卫生保健环境。
Infections caused by community-acquired methicillin-resistant Staphylococcus aureus (MRSA) are emerging as a major public health problem. In this study, we describe the distribution of 54 Panton-Valentine leucocidin (PVL)-carrying MRSA isolates in the northern Netherlands between 1998 and 2005, of which 43 (80%) consisted of the European PVL-positive strain multi locus sequence type 80 with staphylococcal cassette chromosome mec type IVc (ST80). Individual cases and small clusters of ST80 predominated in the community (74%), but ST80 was also found in nursing homes (16%) and hospitals (9%). Long-term carriership (months to years) and reinfection of patients with ST80 has probably led to the strain spreading in the community and subsequently to further migration to health care environments.
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