Global distribution and prevalence of hepatitis C virus genotypes.
Global distribution and prevalence of hepatitis C virus genotypes.
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DOI：
10.1002/hep.27259
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发表时间：
2015-01
期刊：
影响因子：
13.5
通讯作者：
Barnes, Eleanor
中科院分区：
文献类型：
--
作者：
Messina, Jane P.;Humphreys, Isla;Flaxman, Abraham;Brown, Anthony;Cooke, Graham S.;Pybus, Oliver G.;Barnes, Eleanor
丙型肝炎病毒（HCV）具有高度的遗传多样性，其特点是基因型流行的区域差异。这对改进疫苗和泛基因型治疗的开发提出了挑战，这需要考虑HCV基因型流行的全球趋势。在这里，我们提供了这些趋势的第一次全面调查。为了估计国家HCV基因型患病率，对1989年至2013年期间发表的报告HCV基因型的研究进行了审查，并与全球疾病负担（GBD）项目的总体HCV患病率估计值相结合。我们还生成区域和全球基因型患病率估计值，推断缺乏基因型信息的国家的数据。我们在分析中纳入了1，217项研究，代表了117个国家和90%的全球人口。我们计算出HCV基因型1是全球最流行的，包括8340万例病例（占所有HCV病例的46.2%），其中约三分之一在东亚。基因型3是全球下一个最流行的（5430万，30.1%）;基因型2，4和6占所有病例的22.8%;基因型5占剩余的<1%。虽然基因型1和3在大多数国家占主导地位，无论经济地位如何，基因型4和5的比例最大的是在低收入国家。总结：虽然基因型1是最常见的世界范围内，非基因型1的HCV病例，这是不太好的疫苗和药物开发的进步服务，仍然包括超过一半的所有HCV病例。相对基因型比例需要为医疗保健模式提供信息，这些模式必须在地理上针对特定国家或地区进行调整，以改善获得新治疗的机会。需要许多国家提供基因型监测数据，以改进对未满足需求的估计。（肝病学2015;61：77-87）
Hepatitis C virus (HCV) exhibits high genetic diversity, characterized by regional variations in genotype prevalence. This poses a challenge to the improved development of vaccines and pan-genotypic treatments, which require the consideration of global trends in HCV genotype prevalence. Here we provide the first comprehensive survey of these trends. To approximate national HCV genotype prevalence, studies published between 1989 and 2013 reporting HCV genotypes are reviewed and combined with overall HCV prevalence estimates from the Global Burden of Disease (GBD) project. We also generate regional and global genotype prevalence estimates, inferring data for countries lacking genotype information. We include 1,217 studies in our analysis, representing 117 countries and 90% of the global population. We calculate that HCV genotype 1 is the most prevalent worldwide, comprising 83.4 million cases (46.2% of all HCV cases), approximately one-third of which are in East Asia. Genotype 3 is the next most prevalent globally (54.3 million, 30.1%); genotypes 2, 4, and 6 are responsible for a total 22.8% of all cases; genotype 5 comprises the remaining <1%. While genotypes 1 and 3 dominate in most countries irrespective of economic status, the largest proportions of genotypes 4 and 5 are in lower-income countries. Conclusion: Although genotype 1 is most common worldwide, nongenotype 1 HCV cases—which are less well served by advances in vaccine and drug development—still comprise over half of all HCV cases. Relative genotype proportions are needed to inform healthcare models, which must be geographically tailored to specific countries or regions in order to improve access to new treatments. Genotype surveillance data are needed from many countries to improve estimates of unmet need. (Hepatology 2015;61:77–87)
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影响因子：
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作者：
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通讯作者：
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DOI：
10.2471/blt.11.097147
发表时间：
2012-07-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
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影响因子：
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