Uncovering residual effects of chronic sleep loss on human performance.
Uncovering residual effects of chronic sleep loss on human performance.
复制标题
DOI：
10.1126/scitranslmed.3000458
复制
发表时间：
2010-01-13
影响因子：
17.1
通讯作者：
Klerman EB
中科院分区：
文献类型：
--
作者：
Cohen DA;Wang W;Wyatt JK;Kronauer RE;Dijk DJ;Czeisler CA;Klerman EB
睡眠不足会导致严重的性能下降。然而，许多人认为他们适应了慢性睡眠不足，或者恢复只需要一次长时间的睡眠。为了评估这一点，我们设计了一个协议，其中通常的睡眠：觉醒比率从1：2减少到1：3.3，而睡眠和觉醒事件的持续时间分别增加到10小时和32.85小时。这些睡眠和觉醒事件分布在所有昼夜节律阶段，从而能够测量昼夜节律不同时间的急性和慢性睡眠丧失的影响。尽管经常性的急性和大量的慢性睡眠丧失，10小时的睡眠机会始终恢复了几个小时清醒的警觉性。然而，长期睡眠不足增加了清醒状态下的表现恶化率，特别是在昼夜节律的“夜晚”。因此，昼夜节律夜间长时间清醒揭示了慢性睡眠缺失对表现的累积有害影响，具有潜在的不利健康和安全后果。
Sleep loss leads to profound performance decrements. Yet many individuals believe they adapt to chronic sleep loss or that recovery requires only a single extended sleep episode. To evaluate this, we designed a protocol whereby the usual sleep:wake ratio was reduced from 1:2 to 1:3.3, while the durations of both sleep and wake episodes were increased to ten hours and 32.85 hours respectively. These sleep and wake episodes were distributed across all circadian phases, enabling measurement of the effects of acute and chronic sleep loss at different times of the circadian day and night. Despite recurrent acute and substantial chronic sleep loss, ten hour sleep opportunities consistently restored vigilance performance for several hours of wakefulness. However, chronic sleep loss increased the rate of deterioration in performance across wakefulness, particularly during the circadian “night”. Thus, extended wake during the circadian night reveals the cumulative detrimental effects of chronic sleep loss on performance, with potential adverse health and safety consequences.
登录
查看更多内容
影响因子：
3.5
作者：
BROWN, EN;CZEISLER, CA
通讯作者：
CZEISLER, CA
影响因子：
158.5
作者：
Mitler, MM;Miller, JC;Wylie, CD
通讯作者：
Wylie, CD
影响因子：
4.4
作者：
DIJK, DJ;DUFFY, JF;CZEISLER, CA
通讯作者：
CZEISLER, CA
影响因子：
3.5
作者：
Jewett, ME;Kronauer, RE
通讯作者：
Kronauer, RE
影响因子：
5.3
作者：
Blanco-Centurion, Carlos;Xu, Man;Shiromani, Priyattam J.
通讯作者：
Shiromani, Priyattam J.