Prevalence of SARS-CoV-2 infection in previously undiagnosed health care workers in New Jersey, at the onset of the U.S. COVID-19 pandemic.
Prevalence of SARS-CoV-2 infection in previously undiagnosed health care workers in New Jersey, at the onset of the U.S. COVID-19 pandemic.
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DOI：
10.1186/s12879-020-05587-2
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发表时间：
2020-11-16
影响因子：
3.7
通讯作者：
Panettieri RA Jr
中科院分区：
文献类型：
--
作者：
Barrett ES;Horton DB;Roy J;Gennaro ML;Brooks A;Tischfield J;Greenberg P;Andrews T;Jagpal S;Reilly N;Carson JL;Blaser MJ;Panettieri RA Jr
据推测，由于职业暴露于受感染的患者，医务工作者（HCW）感染严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）的风险增加。然而，几乎没有流行病学研究来评估这些风险。我们对HCW（n = 546）和非医护人员（NHCW; n = 283）进行了一项前瞻性队列研究，这些人员从美国一所大型大学和两家附属大学医院招募，既往没有已知的SARS-CoV-2感染。在对基线收集的数据进行横断面分析时，我们通过医护人员的身份和角色检查了SARS-CoV-2感染状态（通过口咽拭子中SARS-CoV-2 RNA的存在来确定）。在基线时，41名（5.0%）参与者的SARS-CoV-2感染检测呈阳性，其中14名（34.2%）报告了症状。HCW中SARS-CoV-2感染的患病率（7.3%）高于NHCW（0.4%），代表绝对风险高7.0%（风险差异的95%置信区间为4.7，9.3%）。感染HCW的大多数（62.5%）是护士。在两周的队列招募期间，阳性检测增加，与医院和周边县确诊病例的增加一致。总体而言，我们的研究结果表明，HCW比NHCW有更高的SARS-CoV-2感染率。对这一队列的持续随访将使我们能够监测感染率并检查传播的风险因素。在线版本包含补充材料，可通过10.1186/s12879-020-05587-2获得。
Healthcare workers (HCW) are presumed to be at increased risk of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection due to occupational exposure to infected patients. However, there has been little epidemiological research to assess these risks. We conducted a prospective cohort study of HCW (n = 546) and non-healthcare workers (NHCW; n = 283) with no known prior SARS-CoV-2 infection who were recruited from a large U.S. university and two affiliated university hospitals. In this cross-sectional analysis of data collected at baseline, we examined SARS-CoV-2 infection status (as determined by presence of SARS-CoV-2 RNA in oropharyngeal swabs) by healthcare worker status and role. At baseline, 41 (5.0%) of the participants tested positive for SARS-CoV-2 infection, of whom 14 (34.2%) reported symptoms. The prevalence of SARS-CoV-2 infection was higher among HCW (7.3%) than in NHCW (0.4%), representing a 7.0% greater absolute risk (95% confidence interval for risk difference 4.7, 9.3%). The majority of infected HCW (62.5%) were nurses. Positive tests increased across the two weeks of cohort recruitment in line with rising confirmed cases in the hospitals and surrounding counties. Overall, our results demonstrate that HCW had a higher prevalence of SARS-CoV-2 infection than NHCW. Continued follow-up of this cohort will enable us to monitor infection rates and examine risk factors for transmission. The online version contains supplementary material available at 10.1186/s12879-020-05587-2.
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