Association of herpes zoster and chronic inflammatory skin disease in US inpatients.
Association of herpes zoster and chronic inflammatory skin disease in US inpatients.
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DOI：
10.1016/j.jaad.2019.12.073
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发表时间：
2021-12
影响因子：
13.8
通讯作者：
Silverberg, Jonathan, I
中科院分区：
文献类型：
--
作者：
Chovatiya, Raj;Silverberg, Jonathan, I
关键词：
慢性炎症性皮肤病（CISD）患者存在带状疱疹（HZ）的潜在危险因素。然而，对CISD中的HZ风险知之甚少。确定CISD是否与HZ关联。数据来自2002-2012年全国住院患者样本，这是美国住院患者的代表性队列（N= 68，088，221名儿童和成人）。在包括年龄、性别、种族/民族、保险、家庭收入和长期全身性皮质类固醇使用的多变量logistic回归模型中，因HZ住院与特应性皮炎相关（调整后OR [95% CI]：1.38 [1.14-1.68]），银屑病（4.78 [2.83-8.08]），天疱疮（1.77 [1.01-3.12]），大疱性类天疱疮（1.77 [1.01-3.12]），蕈样肉芽肿（3.79 [2.55-5.65]），皮肌炎（7.31 [5.27-10.12]），系统性硬化症（1.92 [1.47-2.53]）、皮肤红斑狼疮（1.94 [1.10-3.44]）、白癜风（2.00 [1.04-3.85]）和结节病（1.52 [1.22-1.90]）。扁平苔藓（粗OR [95% CI]：3.01 [1.36-6.67]）、Sézary综合征（12.14 [5.20-28.31]）、硬斑病（2.74 [1.36-5.51]）和坏疽性脓癣（2.44 [1.16-5.13]）仅在双变量模型中显示出比值增加。对60岁以下和50岁以下人群的敏感性分析结果相似。CISD中HZ的预测因素包括女性、较少的慢性疾病和长期全身性皮质类固醇使用。横断面研究。许多CISD与HZ住院率增加相关，甚至低于HZ疫苗接种的推荐年龄。还需要进一步的研究来建立CISD特异性疫苗接种指南。患有各种慢性炎症性皮肤病的患者即使在低于当前疫苗接种指南的年龄也有更高的带状疱疹住院几率，以及住院时间延长和医院护理费用增加。皮肤科医生应考虑这些患者的疾病特异性风险因素，并鼓励提高疫苗接种覆盖率。
Patients with chronic inflammatory skin diseases (CISD) have potential risk factors for herpes zoster (HZ). Yet, little is known about HZ risk in CISD. Determine whether CISD is associated with HZ. Data were analyzed from the 2002–2012 Nationwide Inpatient Sample, a representative cohort of US hospitalizations (N=68,088,221 children and adults). In multivariable logistic regression models including age, sex, race/ethnicity, insurance, household income, and long-term systemic corticosteroid use, hospitalization for HZ was associated with atopic dermatitis (adjusted OR [95% CI]: 1.38 [1.14–1.68]), psoriasis (4.78 [2.83–8.08]), pemphigus (1.77 [1.01–3.12]), bullous pemphigoid (1.77 [1.01–3.12]), mycosis fungoides (3.79 [2.55–5.65]), dermatomyositis (7.31 [5.27–10.12]), systemic sclerosis (1.92 [1.47–2.53]), cutaneous lupus erythematosus (1.94 [1.10–3.44]), vitiligo (2.00 [1.04–3.85]), and sarcoidosis (1.52 [1.22–1.90]). Lichen planus (crude OR [95% CI]: 3.01 [1.36–6.67]), Sézary syndrome (12.14 [5.20–28.31]), morphea (2.74 [1.36–5.51]), and pyoderma gangrenosum (2.44 [1.16–5.13]) only showed increased odds in bivariable models. Sensitivity analyses among ages <60 and <50 years showed similar results. Predictors of HZ in CISD included female sex, fewer chronic conditions, and long-term systemic corticosteroid use. Cross-sectional study. Many CISD are associated with increased hospitalization for HZ, even below ages recommended for HZ vaccination. Additional studies are needed to establish CISD-specific vaccination guidelines. Patients with a variety of chronic inflammatory skin disease had higher odds of hospitalization for herpes zoster even at ages below current vaccination guidelines, as well as prolonged inpatient length of stay and increased cost of hospital care. Dermatologists should consider disease-specific risk factors in these patients and encourage enhanced vaccination coverage.
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DOI：
10.1056/nejmcp1302674
发表时间：
2013-07-18
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cohen JI
通讯作者：
Cohen JI
影响因子：
2.6
作者：
Chakravarty, E. F.;Michaud, K.;Wolfe, F.
通讯作者：
Wolfe, F.
影响因子：
120.7
作者：
AXELROD, PI;LORBER, B;VONDERHEID, EC
通讯作者：
VONDERHEID, EC
影响因子：
--
作者：
DONAHUE, JG;CHOO, PW;PLATT, R
通讯作者：
PLATT, R
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y