CranialVault and its CRAVE tools: a clinical computer assistance system for deep brain stimulation (DBS) therapy.
CranialVault and its CRAVE tools: a clinical computer assistance system for deep brain stimulation (DBS) therapy.
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DOI：
10.1016/j.media.2010.07.009
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发表时间：
2012-04
影响因子：
10.9
通讯作者：
Dawant, Benoit M.
中科院分区：
文献类型：
--
作者：
D'Haese, Pierre-Francois;Pallavaram, Srivatsan;Li, Rui;Remple, Michael S.;Kao, Chris;Neimat, Joseph S.;Konrad, Peter E.;Dawant, Benoit M.
已经开发了许多方法来帮助外科医生在深部脑刺激(DBS)治疗的不同阶段。其中包括构建解剖图谱、功能数据库和电生理图谱和地图。但是，一个可以集成到临床工作流程中的完整系统还没有开发出来。在本文中，我们提出了一个系统，旨在帮助医生进行术前目标规划，术中目标细化和植入，以及术后DBS引导规划。该系统的目的是将获得的数据集中到治疗的各个阶段，减少治疗每个阶段所需的时间，并最大限度地提高整个治疗过程的效率。该系统由一个中央存储库(CranialVault)、一套称为CRAVE(CRAnialVault Explorer)的软件模块组成，该软件模块允许在治疗的每个阶段进行数据输入和数据可视化，以及一系列允许自动处理数据的算法。中央存储库包含400多名患者的图像数据以及相关的术前计划和最终植入物的位置，以及222名患者的约10,550个电生理数据点(微电极记录或对刺激的反应)。该系统已经达到了临床原型的阶段，正在我们机构进行临床评估。对2009年1月至2009年12月期间接受手术的80名患者进行的系统规划部分的初步定量验证表明，该系统提供了及时和有价值的信息。
A number of methods have been developed to assist surgeons at various stages of deep brain stimulation (DBS) therapy. These include construction of anatomical atlases, functional databases, and electrophysiological atlases and maps. But, a complete system that can be integrated into the clinical workflow has not been developed. In this paper we present a system designed to assist physicians in pre-operative target planning, intra-operative target refinement and implantation, and post-operative DBS lead programming. The purpose of this system is to centralize the data acquired a the various stages of the procedure, reduce the amount of time needed at each stage of the therapy, and maximize the efficiency of the entire process. The system consists of a central repository (CranialVault), of a suite of software modules called CRAVE (CRAnialVault Explorer) that permit data entry and data visualization at each stage of the therapy, and of a series of algorithms that permit the automatic processing of the data. The central repository contains image data for more than 400 patients with the related pre-operative plans and position of the final implants and about 10,550 electrophysiological data points (micro-electrode recordings or responses to stimulations) recorded from 222 of these patients. The system has reached the stage of a clinical prototype that is being evaluated clinically at our institution. A preliminary quantitative validation of the planning component of the system performed on 80 patients who underwent the procedure between January 2009 and December 2009 shows that the system provides both timely and valuable information.
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影响因子：
10.6
作者：
D'Haese, PF;Cetinkaya, E;Dawant, BM
通讯作者：
Dawant, BM
影响因子：
4.8
作者：
Nowinski, Wieslaw L.;Belov, Dmitry;Benabid, Alim-Louis
通讯作者：
Benabid, Alim-Louis
影响因子：
11
作者：
Houeto, JL;Mesnage, V;Agid, Y
通讯作者：
Agid, Y
DOI：
10.1007/s11548-009-0391-1
发表时间：
2010-05
影响因子：
3
作者：
Pallavaram, Srivatsan;Dawant, Benoit M.;Remple, Michael S.;Neimat, Joseph S.;Kao, Chris;Konrad, Peter E.;D'Haese, Pierre-Francois
通讯作者：
D'Haese, Pierre-Francois
影响因子：
10.6
作者：
Castro, F. Javier Sanchez;Pollo, Claudio;Thiran, Jean-Philippe
通讯作者：
Thiran, Jean-Philippe