Low Branched Chain Amino Acids and Tyrosine in Thai Patients with Type 2 Diabetes Mellitus Treated with Metformin and Metformin-Sulfonylurea Combination Therapies.
Low Branched Chain Amino Acids and Tyrosine in Thai Patients with Type 2 Diabetes Mellitus Treated with Metformin and Metformin-Sulfonylurea Combination Therapies.
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DOI：
10.3390/jcm10225424
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发表时间：
2021-11-20
影响因子：
3.9
通讯作者：
Tan BK
中科院分区：
文献类型：
--
作者：
Sriboonvorakul N;Pan-Ngum W;Poovorawan K;Muangnoicharoen S;Quinn LM;Tan BK
2型糖尿病（T2 DM）是泰国日益严重的公共卫生挑战（目前患病率约为10.0%）。氨基酸提供了新的生物标志物来预测T2 DM的风险，并指示次优的疾病管理，这可能有助于早期治疗。我们使用液相色谱-质谱法研究了泰国队列中的氨基酸谱，该队列包括T2 DM个体（n = 65，单药治疗; n = 38，多药治疗）与健康对照组（n = 104）。与单次或多次治疗的T2 DM组相比，健康对照组的年龄和BMI显著较低。与健康对照组相比，单次和多次治疗的T2 DM组中的BCAA（亮氨酸和缬氨酸）显著较低（p < 0.001和p < 0.001），并且与健康对照组相比，单次治疗组中的异亮氨酸显著较低（p = 0.014）。这些发现提出了一个问题，即补充支链氨基酸是否有益于单药或多药治疗的T2 DM患者？与健康对照组相比，T2 DM单次和多次给药组中的酪氨酸显著较低（p < 0.001和p = 0.002），而T2 DM多次给药组中的苯丙氨酸显著高于T2 DM单次给药组（p = 0.045）。我们提供了新的见解，糖尿病治疗对这些氨基酸在胰岛素抵抗状态，如T2 DM在一个独特的，但研究不足的泰国人口的影响。
Type 2 diabetes mellitus (T2DM) is a growing public health challenge for Thailand (current prevalence ~10.0%). Amino acids offer novel biomarkers to predict risk of T2DM and indicate sub-optimal disease management, which could facilitate earlier treatment. We studied amino acid profiles in a Thai cohort comprising of individuals with T2DM (n = 65 single-drug-treated; n = 38 multi-drug-treated) compared to healthy controls (n = 104) using liquid chromatography-mass spectrometry. Age and BMI were significantly lower in the healthy controls compared to the single or multi-treated T2DM groups. The BCAA (leucine and valine) were significantly lower in the single and multi-treated T2DM groups compared to healthy controls (p < 0.001 and p < 0.001) and isoleucine was significantly lower in the single-treated compared to the healthy controls (p = 0.014). These findings beg the question whether BCAAs supplementation be beneficial in T2DM patients treated with single or multi-drug therapy? Tyrosine was significantly lower in the single and multi-treated T2DM groups compared to healthy controls (p < 0.001 and p = 0.002), whereas phenylalanine was significantly higher in the multi-treated T2DM group compared to the single treated T2DM group (p = 0.045). We provide novel insights into the effects of diabetes treatments on these amino acids in insulin resistant states such as T2DM in a unique but understudied Thai population.
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影响因子：
5.9
作者：
Jitnarin, Nattinee;Kosulwat, Vongsvat;Poston, Walker S. C.
通讯作者：
Poston, Walker S. C.
高血浆谷氨酸和低谷氨酰胺与谷氨酸的比率与2型糖尿病有关：predimed试验中的病例 - 霍特研究。
DOI：
10.1016/j.numecd.2019.06.005
发表时间：
2019-10
影响因子：
3.9
作者：
Xiaoran Liu;Yan Zheng;Guasch-Ferre, M.;Ruiz-Canela, M.;Toledo, E.;Clish, C.;Liang, L.;Razquin, C.;Corella, D.;Estruch, R.;Fito, M.;Gomez-Gracia, E.;Aros, F.;Ros, E.;Lapetra, J.;Fiol, M.;Serra-Majem, L.;Papandreou, C.;Martinez-Gonzalez, M. A.;Hu, F. B.;Salas-Salvado, J.
通讯作者：
Salas-Salvado, J.
影响因子：
37.8
作者：
Cheng S;Rhee EP;Larson MG;Lewis GD;McCabe EL;Shen D;Palma MJ;Roberts LD;Dejam A;Souza AL;Deik AA;Magnusson M;Fox CS;O'Donnell CJ;Vasan RS;Melander O;Clish CB;Gerszten RE;Wang TJ
通讯作者：
Wang TJ
影响因子：
16.2
作者：
Lee, C. Christine;Watkins, Steve M.;Hanley, Anthony J.
通讯作者：
Hanley, Anthony J.
影响因子：
4.4
作者：
Bao, Yuqian;Zhao, Tie;Jia, Wei
通讯作者：
Jia, Wei