Update on inflammatory breast cancer.

Update on inflammatory breast cancer.
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有关炎症性乳腺癌的最新信息。

DOI:
10.1186/bcr997
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发表时间:
2005
期刊:
Breast cancer research : BCR
影响因子:
--
通讯作者:
Lidereau R
Lidereau R
中科院分区:
其他
文献类型:
--
作者:
Lerebours F;Bieche I;Lidereau R

文献摘要

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炎症性乳腺癌(IBC)是最不常见且最严重的上皮性乳腺癌。诊断是基于临床炎症体征,并通过病理结果得到加强。20年来,国际生物多样性公约的管理工作取得了重大进展。然而,IBC患者的生存率仍然只有非IBC患者的一半。IBC的分子决定因素的鉴定可能会导致更具体的治疗和提高生存率。本文就IBC的分子发病机制的研究进展作一综述。一个更全面的看法可能会获得通过泛基因组分析人类IBC样品,并通过功能在体外和体内测定。这些方法可能在不久的将来提供更好的患者结局。
Inflammatory breast cancer (IBC) is both the least frequent and the most severe form of epithelial breast cancer. The diagnosis is based on clinical inflammatory signs and is reinforced by pathological findings. Significant progress has been made in the management of IBC in the past 20 years. Yet survival among IBC patients is still only one-half that among patients with non-IBC. Identification of the molecular determinants of IBC would probably lead to more specific treatments and to improved survival. In the present article we review recent advances in the molecular pathogenesis of IBC. A more comprehensive view will probably be obtained by pan-genomic analysis of human IBC samples, and by functional in vitro and in vivo assays. These approaches may offer better patient outcome in the near future.
DOI: 10.1038/sj.bjc.6695007
发表时间: 1999-12
影响因子: 8.8
作者:
Forozan, F;Veldman, R;Ammerman, CA;Parsa, NZ;Kallioniemi, A;Kallioniemi, OP;Ethier, SP
通讯作者: Ethier, SP
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