Monitoring the effects of perinatal cannabis and synthetic cannabinoid exposure.
Monitoring the effects of perinatal cannabis and synthetic cannabinoid exposure.
复制标题
监测围产期大麻和合成大麻素暴露的影响。
DOI：
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复制
发表时间：
2020
影响因子：
2.5
通讯作者：
F. Busardò
中科院分区：
文献类型：
--
作者：
J. Carlier;M. Huestis;S. Zaami;S. Pichini;F. Busardò
目的
PURPOSE
Drug use during pregnancy is a critical global challenge, capable of severe impacts on neonatal development. However, the consumption of cannabis and synthetic cannabinoids is on the rise in pregnant women. Obstetric complications with increased risks of miscarriage, fetal growth restriction, and brain development impairment, have been associated with perinatal cannabis exposure, but data on synthetic cannabinoid use during pregnancy is limited.
METHODS
We reviewed studies that investigated the risks associated with cannabis and synthetic cannabinoid use and those that reported the concentrations of cannabinoids and synthetic cannabinoids in maternal (breast milk) and neonatal (placenta, umbilical cord, meconium, and hair) matrices during human pregnancy. A MEDLINE and EMBASE literature search to identify all relevant articles published in English from January 1998 to April 2019 was performed.
RESULTS
Cannabis use during pregnancy is associated with increased risks of adverse obstetrical outcomes, although neurobehavioral effects are still unclear. Analyses of cannabinoids in meconium are well documented, but further research on other unconventional matrices is needed. Adverse effects due to perinatal synthetic cannabinoid exposure are still unknown and analytical data are scarce.
CONCLUSION
Awareness of the hazards of drug use during pregnancy should be improved to encourage health care providers to urge pregnant women to abstain from cannabis and if cannabis-dependent, seek treatment. Moreover, substances used throughout pregnancy should be monitored as a deterrent to cannabis use, and potential cannabis-dependent women should be identified, so as to limit cannabis-fetal exposure during gestation, and provided appropriate treatment.
影响因子：
2.9
作者：
Ashford, Kristin;Fallin-Bennett, Amanda;Lile, Josh
通讯作者：
Lile, Josh