A study of the combined effects of physical activity and air pollution on mortality in elderly urban residents: the Danish Diet, Cancer, and Health Cohort.
A study of the combined effects of physical activity and air pollution on mortality in elderly urban residents: the Danish Diet, Cancer, and Health Cohort.
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DOI：
10.1289/ehp.1408698
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发表时间：
2015-06
影响因子：
10.4
通讯作者：
Nieuwenhuijsen MJ
中科院分区：
文献类型：
--
作者：
Andersen ZJ;de Nazelle A;Mendez MA;Garcia-Aymerich J;Hertel O;Tjønneland A;Overvad K;Raaschou-Nielsen O;Nieuwenhuijsen MJ
体力活动降低了过早死亡的风险，而暴露在空气污染中则增加了过早死亡的风险。体力活动会增强肺部对空气污染物的呼吸吸收和沉积，这可能会增加运动期间空气污染的急性有害影响。我们的目标是研究在城市环境中长期暴露在高空气污染水平下，是否会减缓体力活动对死亡率的好处。来自丹麦饮食、癌症和健康队列的52,061名受试者(年龄在50-65岁)居住在奥胡斯和哥本哈根，他们报告了1993-1997年的体力活动数据，并一直跟踪到2010年。高暴露在空气污染中的定义是居民区模拟二氧化氮(NO2)水平的25%以上。通过COX回归，我们将运动、骑自行车、园艺和散步与总死亡率和特定原因死亡率联系起来，并引入NO2作为交互作用项。总共有5534人死亡：2864人死于癌症，1285人死于心血管疾病，354人死于呼吸系统疾病，122人死于糖尿病。NO2没有改变参与运动、骑自行车和园艺与总死亡率、心血管死亡率和糖尿病死亡率之间的显著负相关。与高NO2暴露(HR=0.77；95%CI：0.54，1.11和HR=0.81；95%CI：0.55，1.18，p交互作用=0.09和0.02)相比，中/低NO2[危险比(HR)=0.55；95%CI：0.42，0.72和0.55；95%CI：0.41，0.73]的参与者与自行车和园艺相关的呼吸系统死亡率的降低更为明显。总体而言，暴露在与交通相关的高水平空气污染中并没有改变相关性，这表明体力活动对死亡率有积极影响。这些新发现需要在其他研究人群中复制。首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容2015年。体育活动和空气污染对老年城市居民死亡率的综合影响的研究：丹麦饮食、癌症和健康队列。环境健康展望123:557–563； http://dx.doi.org/10.1289/ehp.1408698
Physical activity reduces, whereas exposure to air pollution increases, the risk of premature mortality. Physical activity amplifies respiratory uptake and deposition of air pollutants in the lung, which may augment acute harmful effects of air pollution during exercise. We aimed to examine whether benefits of physical activity on mortality are moderated by long-term exposure to high air pollution levels in an urban setting. A total of 52,061 subjects (50–65 years of age) from the Danish Diet, Cancer, and Health cohort, living in Aarhus and Copenhagen, reported data on physical activity in 1993–1997 and were followed until 2010. High exposure to air pollution was defined as the upper 25th percentile of modeled nitrogen dioxide (NO2) levels at residential addresses. We associated participation in sports, cycling, gardening, and walking with total and cause-specific mortality by Cox regression, and introduced NO2 as an interaction term. In total, 5,534 subjects died: 2,864 from cancer, 1,285 from cardiovascular disease, 354 from respiratory disease, and 122 from diabetes. Significant inverse associations of participation in sports, cycling, and gardening with total, cardiovascular, and diabetes mortality were not modified by NO2. Reductions in respiratory mortality associated with cycling and gardening were more pronounced among participants with moderate/low NO2 [hazard ratio (HR) = 0.55; 95% CI: 0.42, 0.72 and 0.55; 95% CI: 0.41, 0.73, respectively] than with high NO2 exposure (HR = 0.77; 95% CI: 0.54, 1.11 and HR = 0.81; 95% CI: 0.55, 1.18, p-interaction = 0.09 and 0.02, respectively). In general, exposure to high levels of traffic-related air pollution did not modify associations, indicating beneficial effects of physical activity on mortality. These novel findings require replication in other study populations. Andersen ZJ, de Nazelle A, Mendez MA, Garcia-Aymerich J, Hertel O, Tjønneland A, Overvad K, Raaschou-Nielsen O, Nieuwenhuijsen MJ. 2015. A study of the combined effects of physical activity and air pollution on mortality in elderly urban residents: the Danish Diet, Cancer, and Health cohort. Environ Health Perspect 123:557–563; http://dx.doi.org/10.1289/ehp.1408698
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影响因子：
13.6
作者：
Peters, Tricia;Brage, Soren;Westgate, Kate;Franks, Paul W.;Gradmark, Anna;Diaz, Maria Jose Tormo;Huerta, Jose Maria;Bendinelli, Benedetta;Vigl, Mattheaus;Boeing, Heiner;Wendel-Vos, Wanda;Spijkerman, Annemieke;Benjaminsen-Borch, Kristin;Valanou, Elisavet;Guillain, Blandine de Lauzon;Clavel-Chapelon, Francoise;Sharp, Stephen;Kerrison, Nicola;Langenberg, Claudia;Arriola, Larraitz;Barricarte, Aurelio;Gonzales, Carlos;Grioni, Sara;Kaaks, Rudolf;Key, Timothy;Khaw, Kay Tee;May, Anne;Nilsson, Peter;Norat, Teresa;Overvad, Kim;Palli, Domenico;Panico, Salvatore;Quiros, Jose Ramon;Ricceri, Fulvio;Sanchez, Maria-Jose;Slimani, Nadia;Tjonneland, Anne;Tumino, Rosario;Feskens, Edith;Riboli, Elio;Ekelund, Ulf;Wareham, Nick
通讯作者：
Wareham, Nick
影响因子：
16.2
作者：
Andersen ZJ;Raaschou-Nielsen O;Ketzel M;Jensen SS;Hvidberg M;Loft S;Tjønneland A;Overvad K;Sørensen M
通讯作者：
Sørensen M
影响因子：
10.4
作者：
Korrick SA;Neas LM;Dockery DW;Gold DR;Allen GA;Hill LB;Kimball KD;Rosner BA;Speizer FE
通讯作者：
Speizer FE
影响因子：
168.9
作者：
Beelen, Rob;Raaschou-Nielsen, Ole;Hoek, Gerard
通讯作者：
Hoek, Gerard
影响因子：
10
作者：
Lundbäck M;Mills NL;Lucking A;Barath S;Donaldson K;Newby DE;Sandström T;Blomberg A
通讯作者：
Blomberg A