Experimental exposure to diesel exhaust increases arterial stiffness in man.
Experimental exposure to diesel exhaust increases arterial stiffness in man.
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DOI：
10.1186/1743-8977-6-7
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发表时间：
2009-03-13
影响因子：
10
通讯作者：
Blomberg A
中科院分区：
文献类型：
--
作者：
Lundbäck M;Mills NL;Lucking A;Barath S;Donaldson K;Newby DE;Sandström T;Blomberg A
暴露于空气污染与心血管疾病发病率增加有关，但其潜在机制尚不清楚。血管功能障碍降低动脉顺应性，增加中心动脉压和左心室后负荷。我们使用一种有效的无创动脉硬度测量方法来确定柴油机废气暴露对动脉顺应性的影响。以双盲随机方式，12名健康志愿者在中度运动期间暴露于柴油废气（约350 μg/m3）或过滤空气1小时。在桡动脉处使用压平张力计测量动脉硬度以进行脉搏波分析（PWA），以及在股动脉和颈动脉处使用压平张力计测量动脉硬度以进行脉搏波速度（PWV）。在暴露后10、20和30 min进行PWA，40 min进行颈动脉-股动脉PWV。计算增强压力（AP）、增强指数（AIx）和波反射时间（Tr）。血压、AP和AIx普遍较低，反映动脉顺应性。与过滤空气相比，柴油机废气暴露诱导AP增加2.5 mmHg（p = 0.02）和AIx增加7.8%（p = 0.01），沿着Tr减少16 ms（p = 0.03），暴露后10分钟。急性暴露于柴油机废气与动脉硬度的立即和短暂增加有关。这可能部分解释了与空气污染暴露相关的心血管疾病风险增加。如果我们的研究结果在更大的易感人群队列中得到证实，这种简单的非侵入性评估动脉硬度的方法可能成为测量真实的世界暴露于燃烧衍生空气污染的影响的有用技术。
Exposure to air pollution is associated with increased cardiovascular morbidity, although the underlying mechanisms are unclear. Vascular dysfunction reduces arterial compliance and increases central arterial pressure and left ventricular after-load. We determined the effect of diesel exhaust exposure on arterial compliance using a validated non-invasive measure of arterial stiffness. In a double-blind randomized fashion, 12 healthy volunteers were exposed to diesel exhaust (approximately 350 μg/m3) or filtered air for one hour during moderate exercise. Arterial stiffness was measured using applanation tonometry at the radial artery for pulse wave analysis (PWA), as well as at the femoral and carotid arteries for pulse wave velocity (PWV). PWA was performed 10, 20 and 30 min, and carotid-femoral PWV 40 min, post-exposure. Augmentation pressure (AP), augmentation index (AIx) and time to wave reflection (Tr) were calculated. Blood pressure, AP and AIx were generally low reflecting compliant arteries. In comparison to filtered air, diesel exhaust exposure induced an increase in AP of 2.5 mmHg (p = 0.02) and in AIx of 7.8% (p = 0.01), along with a 16 ms reduction in Tr (p = 0.03), 10 minutes post-exposure. Acute exposure to diesel exhaust is associated with an immediate and transient increase in arterial stiffness. This may, in part, explain the increased risk for cardiovascular disease associated with air pollution exposure. If our findings are confirmed in larger cohorts of susceptible populations, this simple non-invasive method of assessing arterial stiffness may become a useful technique in measuring the impact of real world exposures to combustion derived-air pollution.
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DOI：
10.1164/rccm.200110-026oc
发表时间：
2002-10-01
影响因子：
24.7
作者：
Nemmar, A;Hoylaerts, MF;Nemery, B
通讯作者：
Nemery, B
DOI：
10.1080/00984100290071658
发表时间：
2002-10-01
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
影响因子：
--
作者：
Oberdörster, G;Sharp, Z;Cox, C
通讯作者：
Cox, C
影响因子：
8.3
作者：
McEniery, Carmel M.;Wallace, Sharon;Wilkinson, Ian B.
通讯作者：
Wilkinson, Ian B.
影响因子：
8.3
作者：
Pauca, AL;O'Rourke, MF;Kon, ND
通讯作者：
Kon, ND
影响因子：
24
作者：
McEniery, CM;Qasem, A;Wilkinson, IB
通讯作者：
Wilkinson, IB