Diet and subsequent survival in women with breast cancer.
Diet and subsequent survival in women with breast cancer.
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DOI：
10.1038/bjc.1994.108
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发表时间：
1994-03
影响因子：
8.8
通讯作者：
Ingram, D.
中科院分区：
文献类型：
--
作者：
Ingram, D.
我们之前的一项研究发现，β-胡萝卜素和维生素 C 的摄入量增加与乳腺癌患者的良好预后指数相关，我们目前对患者 6 年生存期的研究也证实了这一点。目前的研究结果表明，β-胡萝卜素的摄入量是与提高生存率最显着相关的饮食变量。 β-胡萝卜素摄入量最高的组仅发生 1 例死亡，而摄入量中等和最低的组分别有 8 例和 12 例死亡。 β-胡萝卜素可能的抗增殖作用已经被人们认识了一段时间，最近的研究集中在其衍生物视黄酸上，人们发现它可以改善许多组织的分化，包括来自乳腺癌的细胞系。类维生素A与多种肿瘤的显着临床反应相关，并且已经针对许多恶性肿瘤进行了使用β-胡萝卜素的化学预防试验。然而，β-胡萝卜素尚未用于临床试验来评估其治疗乳腺癌的潜力。需要进行大规模临床试验来确定 β-胡萝卜素在降低乳腺癌复发机会和预防新癌症发展方面的有效性。
Our findings from a previous study, that increased consumption of beta-carotene and vitamin C is associated with favourable prognostic indices in patients with breast cancer, have been borne out by our current study of patient survival over a 6-year period. The results of the current study point to beta-carotene consumption as the dietary variable most significantly associated with improved survival. Only one death occurred in the group with the highest consumption of beta-carotene, while there were eight and 12 deaths in the intermediate and lowest groups of consumption respectively. The possible antiproliferative effects of beta-carotene have been recognised for some time, with investigations being focused more recently on its derivative, retinoic acid, which has been found to improve differentiation in many tissues, including cell lines derived from mammary carcinomas. Retinoids have been associated with significant clinical responses in a variety of tumours, and chemoprevention trials using beta-carotene have been undertaken for many malignancies. However, beta-carotene has not yet been used in clinical trials to evaluate its potential for the treatment of breast cancer. A large-scale clinical trial is necessary to determine the effectiveness of beta-carotene in reducing the chances of recurrence of breast cancer, and in preventing the development of new cancers.
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影响因子：
158.5
作者：
HUNTER, DJ;MANSON, JE;WILLETT, WC
通讯作者：
WILLETT, WC
影响因子：
10.3
作者：
VERREAULT, R;BRISSON, J;BELANGER, L
通讯作者：
BELANGER, L
DOI：
10.1016/0027-5107(92)90073-b
发表时间：
1992-06-01
期刊：
MUTATION RESEARCH
影响因子：
--
作者：
KELLOFF, GJ;BOONE, CW;STEELE, VE
通讯作者：
STEELE, VE
影响因子：
10.3
作者：
LIPPMAN, SM;KAVANAGH, JJ;KRAKOFF, IH
通讯作者：
KRAKOFF, IH
影响因子：
8.4
作者：
INGRAM, DM;ROBERTS, A;NOTTAGE, EM
通讯作者：
NOTTAGE, EM