Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders.
Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders.
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DOI：
10.1192/bjp.bp.115.168229
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Eley TC
中科院分区：
文献类型：
--
作者：
Coleman JR;Lester KJ;Keers R;Roberts S;Curtis C;Arendt K;Bögels S;Cooper P;Creswell C;Dalgleish T;Hartman CA;Heiervang ER;Hötzel K;Hudson JL;In-Albon T;Lavallee K;Lyneham HJ;Marin CE;Meiser-Stedman R;Morris T;Nauta MH;Rapee RM;Schneider S;Schneider SC;Silverman WK;Thastum M;Thirlwall K;Waite P;Wergeland GJ;Breen G;Eley TC
背景焦虑症是常见的，认知行为疗法（CBT）是一线治疗。候选基因研究表明，治疗反应的遗传基础，但结果一直不一致。目的对980例焦虑症儿童进行心理治疗反应的首次全基因组关联研究。方法在基线、治疗结束时（治疗后）和治疗结束后3至12个月（随访），采用半结构式访谈评估焦虑的存在和严重程度。使用Illumina Human Core Exome-12v1.0阵列对DNA进行基因分型。使用线性混合模型来检验遗传变异与治疗后即刻和6个月随访时的反应（症状严重程度的变化）之间的关联。结果在两项分析中，没有变异超过全基因组显著性阈值（P = 5 × 10−8）。4个变异符合与治疗后反应相关的提示性显著性标准（P<5 × 10−6），3个变异在6个月随访分析中符合标准。结论这是首次全基因组治疗遗传学研究。这表明，没有非常高的效果的共同变异体对CBT的反应。未来的研究应该通过使用更大、更同质的队列来最大限度地提高检测单变异和多基因效应的能力。
Background Anxiety disorders are common, and cognitive–behavioural therapy (CBT) is a first-line treatment. Candidate gene studies have suggested a genetic basis to treatment response, but findings have been inconsistent. Aims To perform the first genome-wide association study (GWAS) of psychological treatment response in children with anxiety disorders (n = 980). Method Presence and severity of anxiety was assessed using semi-structured interview at baseline, on completion of treatment (post-treatment), and 3 to 12 months after treatment completion (follow-up). DNA was genotyped using the Illumina Human Core Exome-12v1.0 array. Linear mixed models were used to test associations between genetic variants and response (change in symptom severity) immediately post-treatment and at 6-month follow-up. Results No variants passed a genome-wide significance threshold (P = 5 × 10−8) in either analysis. Four variants met criteria for suggestive significance (P<5 × 10−6) in association with response post-treatment, and three variants in the 6-month follow-up analysis. Conclusions This is the first genome-wide therapygenetic study. It suggests no common variants of very high effect underlie response to CBT. Future investigations should maximise power to detect single-variant and polygenic effects by using larger, more homogeneous cohorts.
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来自1,092个人基因组的遗传变异的综合图。
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1177/0269881113495118
发表时间：
2013-09
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
--
作者：
Fineberg NA;Haddad PM;Carpenter L;Gannon B;Sharpe R;Young AH;Joyce E;Rowe J;Wellsted D;Nutt DJ;Sahakian BJ
通讯作者：
Sahakian BJ
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
11
作者：
Bosker, F. J.;Hartman, C. A.;Nolen, W. A.
通讯作者：
Nolen, W. A.
DOI：
10.1016/j.jaac.2015.03.018
发表时间：
2015-06
影响因子：
13.3
作者：
Hudson, Jennifer L.;Keers, Robert;Roberts, Susanna;Coleman, Jonathan R. I.;Breen, Gerome;Arendt, Kristian;Boegels, Susan;Cooper, Peter;Creswell, Cathy;Hartman, Catharina;Heiervang, Einar R.;Hoetzel, Katrin;In-Albon, Tina;Lavallee, Kristen;Lyne-Ham, Heidi J.;Marin, Carla E.;McKinnon, Anna;Meiser-Stedman, Richard;Morris, Talia;Nauta, Maaike;Rapee, Ronald M.;Schneider, Silvia;Schneider, Sophie C.;Silverman, Wendy K.;Thastum, Mikael;Thirlwall, Kerstin;Waite, Polly;Wergeland, Gro Janne;Lester, Kathryn J.;Eley, Thalia C.
通讯作者：
Eley, Thalia C.