Adiponectin induces growth inhibition and apoptosis in cervical cancer HeLa cells
Adiponectin induces growth inhibition and apoptosis in cervical cancer HeLa cells
复制标题
脂联素诱导宫颈癌 HeLa 细胞生长抑制和凋亡
DOI：
10.2478/s11756-011-0063-9
复制
发表时间：
2011-08
期刊：
影响因子：
1.5
通讯作者：
Yan, Jianghua
中科院分区：
文献类型：
--
作者：
Xie, Lianying;Wang, Yongjun;Wang, Shengyu;Wu, Na;Chen, Yuqiang;Yan, Jianghua
Obesity is a known risk factor for postmenopausal cervical cancer. In human, plasma adiponectin (ADPN) levels are inversely associated with obesity. ADPN may influence the pathogenesis of cervical cancer. In this paper, the effects of ADPN on the proliferation of the cervical cancer HeLa cells and its underlying mechanism were studied. We discovered that two ADPN receptors were expressed in HeLa cells and ADPN inhibited the proliferation of HeLa cells. Western-blotting showed that ADPN activated AMP kinase in HeLa cells. Reverse transcriptase-polymerase chain reaction revealed ADPN down-regulated the expression of cell cycle regulators cyclin D1 and c-myc, and induced the expression of p21WAF1/CIP1 and p53. These results indicate that ADPN inhibits proliferation and induces apoptosis of HeLa cells by altering the expression of cell cycle regulators.
登录
查看更多内容
影响因子：
3.8
作者：
Nakayama, Satoshi;Miyoshi, Yasuo;Noguchi, Shinzaburo
通讯作者：
Noguchi, Shinzaburo
DOI：
10.1016/j.bbrc.2005.11.159
发表时间：
2006-02-03
影响因子：
3.1
作者：
Dagon, Y;Avraham, Y;Berry, EM
通讯作者：
Berry, EM
影响因子：
4.7
作者：
G. Pfeiler;G. Hudelist;P. Wülfing;B. Mattsson;R. Königsberg;E. Kubista;C. Singer
通讯作者：
G. Pfeiler;G. Hudelist;P. Wülfing;B. Mattsson;R. Königsberg;E. Kubista;C. Singer
影响因子：
2
作者：
P. Ferroni;R. Palmirotta;A. Spila;F. Martini;V. Raparelli;E. Fossile;S. Mariotti;G. Del Monte;O. Buonomo;M. Roselli;F. Guadagni
通讯作者：
P. Ferroni;R. Palmirotta;A. Spila;F. Martini;V. Raparelli;E. Fossile;S. Mariotti;G. Del Monte;O. Buonomo;M. Roselli;F. Guadagni
DOI：
10.1016/j.bbrc.2006.04.076
发表时间：
2006-06-23
影响因子：
3.1
作者：
Dieudonne, Marie-Noelle;Bussiere, Marianne;Pecquery, Rene
通讯作者：
Pecquery, Rene