Targeting the insulin growth factor receptor 1.
Targeting the insulin growth factor receptor 1.
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DOI：
10.1016/j.hoc.2012.01.004
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发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Helman LJ
中科院分区：
文献类型：
--
作者：
Arnaldez FI;Helman LJ
IGF轴是一个严格控制的内分泌系统，调节细胞生长和发育，已知在癌症生物学中具有重要功能。IGF1和IGF2可以通过旁分泌和自分泌以GH非依赖性方式促进癌症生长，并且还可以赋予对化疗和放疗的抗性。在肿瘤中发现了该系统的许多改变，包括配体和受体表达增加，IGF2基因座杂合子丢失和IGF1R基因拷贝数增加。IGF1网络是靶向治疗的有吸引力的候选者，包括用单克隆抗体和受体下游信号传导的小分子抑制剂阻断受体。本文综述了IGF轴在癌症发生和发展中的作用，并介绍了IGF抑制作为治疗工具的最新进展。
The IGF axis is a tightly controlled endocrine system that regulates cell growth and development, known to have an important function in cancer biology. IGF1 and IGF2 can promote cancer growth in a GH-independent manner both through paracrine and autocrine secretion and can also confer resistance to chemotherapy and radiation. Many alterations of this system have been found in neoplasias, including increased expression of ligands and receptors, loss of heterozigosity of the IGF2 locus and increased IGF1R gene copy number. The IGF1 network is an attractive candidate for targeted therapy, including receptor blockade with monoclonal antibodies and small molecule inhibitors of receptor downstream signaling. This article reviews the role of the IGF axis in the initiation and progression of cancer, and describes the recent advances in IGF inhibition as a therapeutic tool.
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