Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine.
Elevated Creatinine Clearance in Lupus Nephritis patients with Normal Creatinine.
复制标题
DOI：
10.7150/ijms.51117
复制
发表时间：
2021
影响因子：
3.6
通讯作者：
Song L
中科院分区：
文献类型：
--
作者：
Wang S;Wang F;Wang X;Zhang Y;Song L
目的：本研究旨在观察不同尿蛋白水平下血清肌酐正常的系统性红斑狼疮（SLE）患者肌酐清除率（Ccr）的差异。方法：选取2010年1月至2020年4月山东大学齐鲁医院血清肌酐正常的SLE患者177例进行横断面研究。收集以下数据：血尿素氮（BUN）、血清肌酐（Cr）、血清总蛋白、血清白蛋白、免疫球蛋白（Ig） G、IgA、IgM、补体3、补体4、抗ds- dna抗体、尿常规、尿蛋白/肌酐比（UPCR） （G / G）、SLE疾病活动性指数。估计的Ccr根据Cockcroft公式计算。结果：尿蛋白阳性123例（狼疮肾炎，LN组），尿蛋白阴性54例（非LN组）。LN组BUN（5.76±3.22比4.78±1.58，P=0.007）、Cr（62.36±19.53比54.83±11.09，P=0.001）高于非LN组。UPCR与LN患者尿蛋白半定量检测有很强的相关性（r=0.9583， P=0.0417）。尿蛋白3+组（72.97±25.16）和大量蛋白尿组（62.32±19.66）血清肌酐水平显著高于其他组。尿蛋白±组与尿蛋白3+组相比Ccr显著升高（130.6±44.15比110.5±33.50，P=0.02）， UPCR<0.15 g/g组Ccr高于其他组，与UPCR≥0.15 g/g组相比Ccr显著升高（132.44±21.02比115.14±35.89，P=0.007）。结论：LN患者可能存在早期肾功能损害。尿蛋白±或UPCR<0.15 g/g的LN患者肾脏处于功能亢进状态。
Objectives: The present study aimed to observe the differences in creatinine clearance (Ccr) in systemic lupus erythematosus (SLE) patients with normal serum creatinine at different levels of urinary protein. Method: The present cross-sectional study included 177 SLE patients with normal serum creatinine from Qilu Hospital of Shandong University between January 2010 and April 2020. The following data were collected: blood urea nitrogen (BUN), serum creatinine (Cr), serum total protein, serum albumin, immunoglobulin (Ig) G, IgA, IgM, complement 3, complement 4, anti-ds-DNA antibody, routine urine test, urine protein/creatinine ratio (UPCR) (g/g), and the SLE disease activity index. The estimated Ccr was calculated according to the Cockcroft formula. Results: 123 patients were with positive urinary protein (Lupus Nephritis, LN group) and 54 patients were with negative urinary protein (Non-LN group). Compared with the Non-LN group, the LN group had higher BUN (5.76±3.22 vs. 4.78±1.58, P=0.007) and Cr (62.36±19.53 vs. 54.83±11.09, P=0.001). There was a strong correlation between the UPCR and the semi-quantitative determination of urine protein in LN patients (r=0.9583, P=0.0417). The serum creatinine levels were significantly higher in patients with urine protein 3+ (72.97±25.16) or massive proteinuria (62.32±19.66) than the other groups. Patients with urinary protein ± exhibited a significantly elevated Ccr when compared to patients with urinary protein 3+ (130.6±44.15 vs. 110.5±33.50, P=0.02), and patients with UPCR<0.15 g/g had higher Ccr than other groups and showed significantly increased Ccr compared with patients with UPCR≥0.15 g/g (132.44±21.02 vs. 115.14±35.89, P=0.007). Conclusions: Early renal function impairment may be present in LN patients. The kidneys of LN patients with urinary protein ± or UPCR<0.15 g/g are in a state of hyperfunction.
登录
查看更多内容
DOI：
10.1186/cc10013
发表时间：
2011
期刊：
Critical care (London, England)
影响因子：
--
作者：
Minville V;Asehnoune K;Ruiz S;Breden A;Georges B;Seguin T;Tack I;Jaafar A;Saivin S;Fourcade O;Samii K;Conil JM
通讯作者：
Conil JM
DOI：
10.5455/msm.2014.26.122-124
发表时间：
2014-04
期刊：
Materia socio-medica
影响因子：
--
作者：
Ktona E;Barbullushi M;Backa T;Idrizi A;Shpata V;Roshi E
通讯作者：
Roshi E
影响因子：
27.4
作者：
Bertsias GK;Tektonidou M;Amoura Z;Aringer M;Bajema I;Berden JH;Boletis J;Cervera R;Dörner T;Doria A;Ferrario F;Floege J;Houssiau FA;Ioannidis JP;Isenberg DA;Kallenberg CG;Lightstone L;Marks SD;Martini A;Moroni G;Neumann I;Praga M;Schneider M;Starra A;Tesar V;Vasconcelos C;van Vollenhoven RF;Zakharova H;Haubitz M;Gordon C;Jayne D;Boumpas DT;European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
通讯作者：
European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
影响因子：
3.4
作者：
Chotayaporn, Thanyaluk;Kasitanon, Nuntana;Louthrenoo, Worawit
通讯作者：
Louthrenoo, Worawit
影响因子：
1.1
作者：
Hsieh, Yao P.;Wen, Yao K.;Chen, Moi L.
通讯作者：
Chen, Moi L.