Determination of the tumor tissue optical properties during and after photodynamic therapy using inverse Monte Carlo method and double integrating sphere between 350 and 1000 nm.
Determination of the tumor tissue optical properties during and after photodynamic therapy using inverse Monte Carlo method and double integrating sphere between 350 and 1000 nm.
复制标题
使用反蒙特卡罗方法和 350 至 1000 nm 之间的双积分球测定光动力治疗期间和之后的肿瘤组织光学特性。
DOI：
--
复制
发表时间：
2011
影响因子：
3.5
通讯作者：
K. Awazu
中科院分区：
文献类型：
--
作者：
N. Honda;K. Ishii;Takaya Terada;Takuya Nanjo;K. Awazu
光动力疗法（PDT）的疗效取决于组织内的光分布量。然而，传统的PDT在PDT期间不考虑激光照射剂量。生物组织的光学特性（吸收系数μ（α）、约化散射系数μ s、各向异性因子g、折射率等）帮助我们识别光在组织中的传播。本文的目的是通过光动力治疗小鼠肿瘤组织的光学特性，了解光动力治疗过程中及治疗后组织内光的传播规律。利用双积分球装置和基于逆蒙特卡罗方法的算法在350 ~ 1000 nm波长范围内对小鼠肿瘤组织的光学性质进行了评价。PDT过程中，μ（a）和μ s在照射1和5 min后无明显变化。PDT后，在600 - 1000 nm波长范围内的μ s随时间的推移而增加。PDT后7天，μ s增加1.7 ~ 2.0倍，光穿透深度减小1.4 ~ 1.8倍。为了确保有效的程序，激光参数的调整，为减少穿透深度的PDT的再照射建议。
Photodynamic therapy (PDT) efficacy depends on the amount of light distribution within the tissue. However, conventional PDT does not consider the laser irradiation dose during PDT. The optical properties of biological tissues (absorption coefficient μ(a), reduced scattering coefficient μ's), anisotropy factor g, refractive index, etc.) help us to recognize light propagation through the tissue. The goal of this paper is to acquire the knowledge of the light propagation within tissue during and after PDT with the optical property of PDT-performed mouse tumor tissue. The optical properties of mouse tumor tissues were evaluated using a double integrating sphere setup and the algorithm based on the inverse Monte Carlo method in the wavelength range from 350 to 1000 nm. During PDT, the μ(a) and μ's were not changed after 1 and 5 min of irradiation. After PDT, the μ's in the wavelength range from 600 to 1000 nm increased with the passage of time. For seven days after PDT, the μ's increased by 1.7 to 2.0 times, which results in the optical penetration depth decreased by 1.4 to 1.8 times. To ensure an effective procedure, the adjustment of laser parameters for the decreasing penetration depth is recommended for the re-irradiation of PDT.
影响因子：
6.1
作者：
WANG, LH;JACQUES, SL;ZHENG, LQ
通讯作者：
ZHENG, LQ
DOI：
10.1016/j.jphotobiol.2004.09.013
发表时间：
2005-06-01
影响因子：
5.4
作者：
Zhu, TC;Finlay, JC;Hahn, SM
通讯作者：
Hahn, SM
影响因子：
10.3
作者：
NELSON, JS;LIAW, LH;BERNS, MW
通讯作者：
BERNS, MW