Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
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DOI：
10.3390/antiox10081249
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发表时间：
2021-08-04
期刊：
影响因子：
--
通讯作者：
Zamora-Ros R
中科院分区：
文献类型：
--
作者：
Londoño C;Cayssials V;de Villasante I;Crous-Bou M;Scalbert A;Weiderpass E;Agudo A;Tjønneland A;Olsen A;Overvad K;Katzke V;Schulze M;Palli D;Krogh V;Santucci de Magistris M;Tumino R;Ricceri F;Gram IT;Rylander C;Skeie G;Sánchez MJ;Amiano P;Huerta JM;Barricarte A;Sartor H;Sonestedt E;Esberg A;Idahl A;Mahamat-Saleh Y;Laouali N;Kvaskoff M;Turzanski-Fortner R;Zamora-Ros R
尽管从病例对照研究中获得了一些关于多酚摄入对上皮性卵巢癌（EOC）风险的保护作用的流行病学证据，但前瞻性研究中的证据很少，并且对于几种多酚类不存在。因此，我们的目的是在一项大型前瞻性研究中调查总多酚、多酚类和多酚亚类的摄入量与EOC风险之间的关系。这项研究是在欧洲癌症和营养前瞻性调查（EPIC）队列中进行的，其中包括309，129名成年女性，主要来自普通人群。多酚摄入量是通过验证国家特定的饮食问卷和酚资源管理器数据库进行评估。在平均14年的随访中，确定了1469例首次发生的EOC病例（包括806例浆液性、129例类浆液性、102例粘液性和67例透明细胞肿瘤）。在多变量校正的考克斯回归模型中，总多酚摄入量最高四分位数与最低四分位数（HRQ 4与Q1）的风险比为1.14（95%CI 0.94-1.39; p趋势= 0.11）。同样，大多数多酚类和亚类的摄入量与总体EOC风险或任何EOC亚型无关。观察到酚酸摄入量（HRQ 4vsQ 1 = 1.20，95%CI 1.01-1.43; p趋势= 0.02）与EOC风险之间存在临界统计学显著正相关，尤其是对于浆液性亚型和肥胖女性，尽管这些相关性未超过Bonferroni校正阈值。目前的结果不支持我们在欧洲进行的大型前瞻性研究中多酚摄入量与EOC之间的任何关联。关于酚酸摄入量的结果需要进一步调查
Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours) were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest quartile of total polyphenol intake compared with the lowest quartile (HRQ4vsQ1) was 1.14 (95% CI 0.94–1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were not related to either overall EOC risk or any EOC subtype. A borderline statistically significant positive association was observed between phenolic acid intake (HRQ4vsQ1 = 1.20, 95% CI 1.01–1.43; p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although these associations did not exceed the Bonferroni correction threshold. The current results do not support any association between polyphenol intake and EOC in our large European prospective study. Results regarding phenolic acid intake need further investigation
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DOI：
10.3945/ajcn.114.088708
发表时间：
2014-11
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Cassidy A;Huang T;Rice MS;Rimm EB;Tworoger SS
通讯作者：
Tworoger SS
DOI：
10.1016/s1470-2045(12)70322-4
发表时间：
2012-09
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Collaborative Group on Epidemiological Studies of Ovarian Cancer;Beral V;Gaitskell K;Hermon C;Moser K;Reeves G;Peto R
通讯作者：
Peto R
DOI：
10.1158/1055-9965.epi-13-0515
发表时间：
2014-02
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Crane TE;Khulpateea BR;Alberts DS;Basen-Engquist K;Thomson CA
通讯作者：
Thomson CA
影响因子：
7.7
作者：
Ong, Jue-Sheng;Hwang, Liang-Dar;MacGregor, Stuart
通讯作者：
MacGregor, Stuart
DOI：
10.5604/12321966.1233565
发表时间：
2018-01-01
影响因子：
1.7
作者：
Plagens-Rotman, Katarzyna;Chmaj-Wierzchowska, Karolina;Bojar, Iwona
通讯作者：
Bojar, Iwona