Brain Organization in Schizophrenia
Brain Organization in Schizophrenia
复制标题
精神分裂症的大脑组织
DOI：
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复制
发表时间：
1986
影响因子：
6.3
通讯作者：
J. Overall
中科院分区：
文献类型：
--
作者：
N. Volkow;J. Brodie;A. Wolf;F. Gómez;R. Cancro;P. Van Gelder;J. Russell;J. Overall
在基线和视觉任务期间，用正电子发射断层扫描和[11C]脱氧葡萄糖测量了12名正常人和18名精神分裂症患者的脑代谢。通过将11个大脑区域的整体代谢值除以整个大脑的代谢值，将其转换为相对值。在基线和任务条件下，对正常人和精神分裂症患者相对区域值的相互关系矩阵进行因子分析。四个因素揭示了独立变化的代谢额，枕，左右半球，和皮层下结构。额叶因子和皮层下因子区分正常受试者和精神分裂症患者，枕叶因子区分基线和任务。尽管这些个体区域的活性差异很大，但区域代谢活性的差异模式是诊断组和测试条件之间最好的区分。
Brain metabolism was measured with positron emission tomography and [11C]deoxyglucose during baseline and during a visual task in 12 normal subjects and 18 schizophrenic patients. Global measures of metabolism for 11 brain regions were transformed into relative values by dividing them by the metabolic value for whole brain. Factor analysis was accomplished on the matrix of intercorrelations among the relative regional values for the normal and for the schizophrenic patients under baseline and under the task. Four factors that revealed independently varying metabolism in frontal, occipital, left-versus-right hemisphere, and subcortical structures were obtained. The frontal and subcortical factors discriminated between normal subjects and schizophrenic patients, whereas the occipital factor discriminated between baseline and task. Although activity in these individual regions varied significantly, it was the pattern of differences in regional metabolic activity that best discriminated between diagnostic groups and testing conditions.
DOI：
10.1176/ajp.142.5.564
发表时间：
1985-05
期刊：
The American journal of psychiatry
影响因子：
--
作者：
A. Wolkin;J. Jaeger;J. Brodie;A. Wolf;J. Fowler;J. Rotrosen;F. Gómez-Mont;R. Cancro
通讯作者：
A. Wolkin;J. Jaeger;J. Brodie;A. Wolf;J. Fowler;J. Rotrosen;F. Gómez-Mont;R. Cancro
慢性精神分裂症的区域脑葡萄糖代谢。
影响因子：
--
作者：
Farkas,T;Wolf,AP;Jaeger,J;Brodie,JD;Christman,DR;Fowler,JS
通讯作者：
Fowler,JS